A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation

A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation

DNA double-strand breaks (DSB) elicit a ubiquitylation cascade that controls DNA repair pathway choice. This cascade involves the ubiquitylation of histone H2A by the RNF168 ligase and the subsequent recruitment of RIF1, which suppresses homologous recombination (HR) in G1 cells. The RIF1-dependent...

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Bibliographic Details
Main Authors:	Luijsterburg, MS, Typas, D, Caron, M-C, Wiegant, WW, Van Den Heuvel, D, Boonen, RA, Couturier, AM, Mullenders, LH, Masson, J-Y, Van Attikum, H
Format:	Journal article
Language:	English
Published:	eLife Sciences Publications 2017

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