Molecular monitoring of the Leu-164 mutation of dihydrofolate reductase in a highly sulfadoxine/pyrimethamine-resistant area in Africa.

The selection of point mutation at codon 164 (from isoleucine to leucine) of the dihydrofolate reductase (DHFR) enzyme in Plasmodium falciparum is associated with high sulfadoxine /pyrimethamine (SP) resistance. Using the yeast expression system that allows the detection of dhfr allele present at lo...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Ochong, E, Nzila, A, Kimani, S, Kokwaro, G, Mutabingwa, T, Watkins, W, Marsh, K
Fformat: Journal article
Iaith:English
Cyhoeddwyd: BioMed Central 2003