Attenuation of influenza A virus mRNA levels by promoter mutations.

Attenuation of influenza A virus mRNA levels by promoter mutations.

We have engineered influenza A/WSN/33 viruses which have viral RNA (vRNA) segments with altered base pairs in the conserved double-stranded region of their vRNA promoters. The mutations were introduced into the segment coding for the neuraminidase (NA) by using a reverse genetics system. Two of the...

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Bibliographic Details
Main Authors:	Fodor, E, Palese, P, Brownlee, G, García-Sastre, A
Format:	Journal article
Language:	English
Published:	1998

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