Attenuation of influenza A virus mRNA levels by promoter mutations.
We have engineered influenza A/WSN/33 viruses which have viral RNA (vRNA) segments with altered base pairs in the conserved double-stranded region of their vRNA promoters. The mutations were introduced into the segment coding for the neuraminidase (NA) by using a reverse genetics system. Two of the...
Автори: | Fodor, E, Palese, P, Brownlee, G, García-Sastre, A |
---|---|
Формат: | Journal article |
Мова: | English |
Опубліковано: |
1998
|
Схожі ресурси
Схожі ресурси
-
Reduced levels of neuraminidase of influenza A viruses correlate with attenuated phenotypes in mice.
за авторством: Solorzano, A, та інші
Опубліковано: (2000) -
Polyuridylated mRNA synthesized by a recombinant influenza virus is defective in nuclear export.
за авторством: Poon, L, та інші
Опубліковано: (2000) -
Mutational analysis of the RNA-fork model of the influenza A virus vRNA promoter in vivo.
за авторством: Kim, H, та інші
Опубліковано: (1997) -
Polyadenylation of influenza virus mRNA transcribed in vitro from model virion RNA templates: requirement for 5' conserved sequences.
за авторством: Pritlove, D, та інші
Опубліковано: (1998) -
Rescue of influenza A virus from recombinant DNA.
за авторством: Fodor, E, та інші
Опубліковано: (1999)