Structure and mechanism of arylamine N-acetyltransferases.

Structure and mechanism of arylamine N-acetyltransferases.

Arylamine N-acetyltransferases (NATs) are a family of phase II drug-metabolising enzymes which are important in the biotransformation of various aromatic and heterocyclic amines and hydroxylamines, arylhydrazines and arylhydrazides. NATs are present in a wide range of eukaryotes and prokaryotes. Hum...

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Bibliografiske detaljer
Main Authors:	Westwood, I, Kawamura, A, Fullam, E, Russell, A, Davies, S, Sim, E
Format:	Journal article
Sprog:	English
Udgivet:	2006

Lignende værker

Arylamine N-acetyltransferases: structural and functional implications of polymorphisms.
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Udgivet: (2008)

Comparison of the Arylamine N-acetyltransferase from Mycobacterium marinum and Mycobacterium tuberculosis.
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Structural Studies on the Mycobacterial Arylamine N-Acetyltransferases
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Design, synthesis and structure-activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase.
af: Fullam, E, et al.
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Design, synthesis and structure-activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase.
af: Fullam, E, et al.
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Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars.
af: Westwood, I, et al.
Udgivet: (2010)

Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding
af: Laurieri, N, et al.
Udgivet: (2014)

Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2.
af: Russell, A, et al.
Udgivet: (2009)

Novel small-molecule inhibitors of arylamine N-acetyltransferases: drug discovery by high-throughput screening.
af: Westwood, I, et al.
Udgivet: (2011)

Arylamine N-acetyltransferase in adult mouse brain
af: Mo, M, et al.
Udgivet: (2004)

Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site.
af: Abuhammad, A, et al.
Udgivet: (2010)

Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages
af: Abuhammad, A, et al.
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Neuroendocrine expression of mouse arylamine N-acetyltransferase 2
af: Wakefield, L, et al.
Udgivet: (2006)

Structural investigation of mutant Mycobacterium smegmatis arylamine N-acetyltransferase: a model for a naturally occurring functional polymorphism in Mycobacterium tuberculosis arylamine N-acetyltransferase.
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Udgivet: (2003)

Small molecule colorimetric probes for specific detection of human arylamine N-acetyltransferase 1, a potential breast cancer biomarker.
af: Laurieri, N, et al.
Udgivet: (2010)

An approach to identifying novel substrates of bacterial arylamine N-acetyltransferases.
af: Brooke, E, et al.
Udgivet: (2003)

Synthesis and in vitro evaluation of novel small molecule inhibitors of bacterial arylamine N-acetyltransferases (NATs).
af: Brooke, E, et al.
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Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages.
af: Areej Abuhammad, et al.
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Over-expression, purification, and characterization of recombinant human arylamine N-acetyltransferase 1.
af: Wang, H, et al.
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Eukaryotic arylamine N-acetyltransferase. Investigation of substrate specificity by high-throughput screening.
af: Kawamura, A, et al.
Udgivet: (2005)

Mapping the genes for arylamine N-acetyltransferases
af: Fakis, G
Udgivet: (2000)

Inhibition of mycobacterial arylamine N-acetyltransferase contributes to anti-mycobacterial activity of Warburgia salutaris.
af: Madikane, V, et al.
Udgivet: (2007)

Inhibition of mycobacterial arylamine N-acetyltransferase contributes to anti-mycobacterial activity of Warburgia salutaris
af: Madikane, V, et al.
Udgivet: (2007)

Arylamine N-acetyltransferase expression during murine heart development
af: Wakefield, L, et al.
Udgivet: (2004)

Hamster arylamine N-acetyltransferase 2: Investigation of substrate specificity by high-through-put screening
af: Kawamura, A, et al.
Udgivet: (2004)

The structure of arylamine N-acetyltransferase from Mycobacterium smegmatis--an enzyme which inactivates the anti-tubercular drug, isoniazid.
af: Sandy, J, et al.
Udgivet: (2002)

Expression of the genes for arylamine N-acetyltransferases in mice
af: Boukouvala, S, et al.
Udgivet: (2002)

Characterization of the putative operon containing arylamine N-acetyltransferase (nat) in Mycobacterium bovis BCG.
af: Anderton, M, et al.
Udgivet: (2006)

Protein-ligand interactions of arylamine N-acetyltransferase from Mycobacterium smegmatis
af: Brooke, E
Udgivet: (2003)

Arylamine N-acetyltransferase 2 gene polymorphism in an Algerian population
af: Hiba Chelouti, et al.
Udgivet: (2017-08-01)

Biochemical Characterization of Arylamine N-acetyltransferases From Vibrio vulnificus
af: Xinning Liu, et al.
Udgivet: (2021-01-01)

Arylamine N-Acetyltransferase 1 Activity is Regulated by the Protein Acetylation Status
af: Raúl A. Salazar-González, et al.
Udgivet: (2022-01-01)

Mouse arylamine N-acetyltransferase 2 (Nat2) expression during embryogenesis: a potential marker for the developing neuroendocrine system.
af: Wakefield, L, et al.
Udgivet: (2008)

Polymorphisms of arylamine N-acetyltransferase2 and risk of lung and colorectal cancer
af: Amjad Mahasneh, et al.
Udgivet: (2012-01-01)

Mouse N-acetyltransferase type 2, the homologue of human N-acetyltransferase type 1.
af: Kawamura, A, et al.
Udgivet: (2008)

A novel color change mechanism for breast cancer biomarker detection: naphthoquinones as specific ligands of human arylamine N-acetyltransferase 1
af: Laurieri, N, et al.
Udgivet: (2013)

Characterization of the putative operon containing arylamine N−acetyltransferase (nat) in Mycobacterium bovis BCG
af: Eltis, E
Udgivet: (2006)

Distribution of arylamine N-acetyltransferase 2 (NAT2) genotypes among Omanis
af: Musbah O. M. Tanira, et al.
Udgivet: (2003-04-01)

Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase.
af: Fullam, E, et al.
Udgivet: (2011)

Humans and Chimpanzees Display Opposite Patterns of Diversity in Arylamine N-Acetyltransferase Genes
af: Christelle Vangenot, et al.
Udgivet: (2019-07-01)