MHC Hammer reveals genetic and non-genetic HLA disruption in cancer evolution

MHC Hammer reveals genetic and non-genetic HLA disruption in cancer evolution

Disruption of the class I human leukocyte antigen (HLA) molecules has important implications for immune evasion and tumor evolution. We developed major histocompatibility complex loss of heterozygosity (LOH), allele-specific mutation and measurement of expression and repression (MHC Hammer). We iden...

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Bibliographic Details
Main Authors: Puttick, C, Jones, TP, Leung, MM, Galvez-Cancino, F, Liu, J, Varas-Godoy, M, Rowan, A, Pich, O, Martinez-Ruiz, C, Bentham, R, Dijkstra, KK, Black, JRM, Rosenthal, R, Kanu, N, Litchfield, K, Salgado, R, Moore, DA, Van Loo, P, Jamal-Hanjani, M, Quezada, SA, Swanton, C, McGranahan, N
Format: Journal article
Language:English
Published: Nature Research 2024

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