Independent recombination events between the duplicated human alpha globin genes; implications for their concerted evolution.

Independent recombination events between the duplicated human alpha globin genes; implications for their concerted evolution.

We have examined the molecular structure of the human alpha globin gene complex from individuals with a common form of alpha thalassaemia in which one of the duplicated pair of alpha genes (alpha alpha) has been deleted (-alpha 3-7). Restriction mapping and DNA sequence analysis of the mutants indic...

书目详细资料
Main Authors:	Higgs, D, Hill, A, Bowden, D, Weatherall, D, Clegg, J
格式:	Journal article
语言:	English
出版:	1984

相似书籍

Alpha globin genotypes in two North European populations.
由: Flint, J, et al.
出版: (1986)

GEOGRAPHIC-DISTRIBUTION OF ALPHA-GLOBIN AND BETA-GLOBIN GENE-CLUSTER POLYMORPHISMS
由: Wainscoat, J, et al.
出版: (1989)

Molecular rearrangements of the human alpha-globin gene cluster.
由: Higgs, D, et al.
出版: (1985)

THE ALPHA-3.7 AND ALPHA-4.2 DELETION FORMS OF ALPHA+-THALASSAEMIA DIFFER IN SEVERITY
由: Hill, A, et al.
出版: (1985)

Chromosomes with one, two, three, and four fetal globin genes: molecular and hematologic analysis.
由: Hill, A, et al.
出版: (1986)

Globin genes in Micronesia: origins and affinities of Pacific Island peoples.
由: O'Shaughnessy, D, et al.
出版: (1990)

Different hematologic phenotypes are associated with the leftward (-alpha 4.2) and rightward (-alpha 3.7) alpha+-thalassemia deletions.
由: Bowden, D, et al.
出版: (1987)

A silent deletion in the beta-globin gene cluster.
由: Tate, V, et al.
出版: (1986)

The structure of a human alpha-globin pseudogene and its relationship to alpha-globin gene duplication.
由: Proudfoot, N, et al.
出版: (1980)

THE ASSOCIATION OF ALPHA-THALASSEMIA AND MALARIA IN MELANESIA
由: Flint, J, et al.
出版: (1986)

Long-range regulation of alpha-globin gene expression.
由: Higgs, D, et al.
出版: (2008)

Interaction of five globin gene abnormalities in a Cambodian family.
由: Simpkins, H, et al.
出版: (1986)

The mouse alpha-globin locus regulatory element.
由: Gourdon, G, et al.
出版: (1995)

Long-range regulation of alpha globin gene expression during erythropoiesis.
由: Higgs, D, et al.
出版: (2008)

Melanesians and Polynesians share a unique alpha-thalassemia mutation.
由: Hill, A, et al.
出版: (1985)

The evolution of the alpha- and beta-globin gene clusters in human populations.
由: Hill, A, et al.
出版: (1986)

Polynesian origins and affinities: globin gene variants in eastern Polynesia.
由: Hill, A, et al.
出版: (1987)

Analysis of the human alpha-globin gene cluster in transgenic mice.
由: Sharpe, J, et al.
出版: (1993)

COMPARISON OF THE ALPHA-GLOBIN GENE-CLUSTER STRUCTURE IN PERISSODACTYLA
由: Flint, J, et al.
出版: (1990)

The role of histone deacetylases in repressing alpha-globin gene expression in non-erythroid cells.
由: Garrick, D, et al.
出版: (2003)

Deletion of the alpha-globin gene cluster as a cause of acquired alpha-thalassemia in myelodysplastic syndrome.
由: Steensma, D, et al.
出版: (2004)

The mechanism of alpha-globin activation during erythropoiesis
由: Higgs, D, et al.
出版: (2007)

The alpha thalassaemias.
由: Higgs, D, et al.
出版: (2009)

Relative roles of genetic factors, dietary deficiency, and infection in anaemia in Vanuatu, South-West Pacific.
由: Bowden, D, et al.
出版: (1985)

Beta thalassaemia intermedia due to co-inheritance of three unique alpha globin cluster duplications characterised by next generation sequencing analysis
由: Clark, B, et al.
出版: (2016)

Understanding α-globin gene regulation and implications for the treatment of β-thalassemia
由: Mettananda, S, et al.
出版: (2016)

CHARACTERIZATION OF BETA-GLOBIN MESSENGER-RNA IN BETA-O THALASSEMIAS
由: Old, J, et al.
出版: (1978)

Characterization of beta-globin mRNA in the beta0 thalassemias.
由: Old, J, et al.
出版: (1978)

Structure and evolution of the horse zeta globin locus.
由: Flint, J, et al.
出版: (1988)

Alpha thalassaemia in British people.
由: Higgs, D, et al.
出版: (1985)

Does Transcription of Remote alpha-Globin Regulatory Elements Affect Their Function?
由: Kowalczyk, MS, et al.
出版: (2009)

Concerted evolution of duplicated mitochondrial control regions in three related seabird species
由: Birt Tim P, et al.
出版: (2010-01-01)

Recombination within the human embryonic xi-globin locus: a common xi-xi chromosome produced by gene conversion of the psi xi gene.
由: Hill, A, et al.
出版: (1985)

Alpha-thalassaemia and the malaria hypothesis.
由: Hill, A, et al.
出版: (1987)

Understanding alpha-globin gene regulation: Aiming to improve the management of thalassemia.
由: Higgs, D, et al.
出版: (2005)

Multiple origins of the sickle mutation: evidence from beta S globin gene cluster polymorphisms.
由: Wainscoat, J, et al.
出版: (1983)

Analysis of the human alpha-globin gene cluster reveals a highly informative genetic locus.
由: Higgs, D, et al.
出版: (1986)

De novo deletion within the telomeric region flanking the human alpha globin locus as a cause of alpha thalassaemia.
由: Viprakasit, V, et al.
出版: (2003)

A novel deletion causing alpha thalassemia clarifies the importance of the major human alpha globin regulatory element.
由: Viprakasit, V, et al.
出版: (2006)

Alpha-thalassaemia caused by a polyadenylation signal mutation.
由: Higgs, D, et al.
出版: (1983)