Early treatment failure in severe malaria resulting from abnormally low plasma quinine concentrations.

A patient admitted with severe Plasmodium falciparum malaria in western Thailand had an early treatment failure with quinine, despite full dosing. Plasma quinine concentrations were subtherapeutic. Abnormal quinine pharmacokinetics may explain sporadic reports of quinine treatment failures in severe...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính: Newton, P, Ward, S, Angus, B, Chierakul, W, Dondorp, A, Ruangveerayuth, R, Silamut, K, Teerapong, P, Suputtamongkol, Y, Looareesuwan, S, White, N
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 2006
Miêu tả
Tóm tắt:A patient admitted with severe Plasmodium falciparum malaria in western Thailand had an early treatment failure with quinine, despite full dosing. Plasma quinine concentrations were subtherapeutic. Abnormal quinine pharmacokinetics may explain sporadic reports of quinine treatment failures in severe malaria.