Separate processes mediate nucleotide-induced inhibition and stimulation of the ATP-regulated K(+)-channels in mouse pancreatic beta-cells.

Separate processes mediate nucleotide-induced inhibition and stimulation of the ATP-regulated K(+)-channels in mouse pancreatic beta-cells.

The mechanisms by which nucleotides stimulate the activity of the ATP-regulated K(+)-channel (KATP-channel) were investigated using inside-out patches from mouse pancreatic beta-cells. ATP produces a concentration-dependent inhibition of channel activity with a Ki of 18 microns. The inhibitory actio...

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Detalles Bibliográficos
Autores principales: Bokvist, K, Ammälä, C, Ashcroft, F, Berggren, P, Larsson, O, Rorsman, P
Formato: Journal article
Lenguaje:English
Publicado: 1991

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