Separate processes mediate nucleotide-induced inhibition and stimulation of the ATP-regulated K(+)-channels in mouse pancreatic beta-cells.

Separate processes mediate nucleotide-induced inhibition and stimulation of the ATP-regulated K(+)-channels in mouse pancreatic beta-cells.

The mechanisms by which nucleotides stimulate the activity of the ATP-regulated K(+)-channel (KATP-channel) were investigated using inside-out patches from mouse pancreatic beta-cells. ATP produces a concentration-dependent inhibition of channel activity with a Ki of 18 microns. The inhibitory actio...

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Bibliografiske detaljer
Main Authors:	Bokvist, K, Ammälä, C, Ashcroft, F, Berggren, P, Larsson, O, Rorsman, P
Format:	Journal article
Sprog:	English
Udgivet:	1991

Lignende værker

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Exocytosis elicited by action potentials and voltage-clamp calcium currents in individual mouse pancreatic B-cells.
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Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells.
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Modification of K-ATP channels in pancreatic beta-cells by trypsin.
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Simultaneous recordings of glucose dependent electrical activity and ATP-regulated K(+)-currents in isolated mouse pancreatic beta-cells.
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Effects of internal chloride on ATP-sensitive K-channels in mouse pancreatic beta-cells.
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Effects of intracellular pH on ATP-sensitive K+ channels in mouse pancreatic beta-cells.
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THE EFFECT OF INTRACELLULAR PH ON ATP-SENSITIVE K+ CHANNELS IN ISOLATED MOUSE PANCREATIC BETA-CELLS
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SINGLE CALCIUM-CHANNEL ACTIVITY IN MOUSE PANCREATIC BETA-CELLS
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Single calcium channel activity in mouse pancreatic beta-cells.
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Glucose dependent K+-channels in pancreatic beta-cells are regulated by intracellular ATP.
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Inhibition of ATP-regulated K+ channels precedes depolarization-induced increase in cytoplasmic free Ca2+ concentration in pancreatic beta-cells.
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EFFECTS OF TRYPSIN ON ATP-DEPENDENT-K+ CHANNELS FROM PANCREATIC BETA-CELLS
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BLOCK OF ATP-SENSITIVE K+ CHANNELS IN ISOLATED MOUSE PANCREATIC BETA-CELLS BY 2,3-BUTANEDIONE MONOXIME
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