Paracrine effect of GTP cyclohydrolase and angiopoietin-1 interaction in stromal fibroblasts on tumor Tie2 activation and breast cancer growth.

Paracrine effect of GTP cyclohydrolase and angiopoietin-1 interaction in stromal fibroblasts on tumor Tie2 activation and breast cancer growth.

Cancer-associated fibroblasts (CAFs) play a key role in promoting tumor growth, acting through complex paracrine regulation. GTP cyclohydrolase (GTPCH) expression for tetrahydrobiopterin synthesis in tumor stroma is implicated in angiogenesis and tumor development. However, the clinical significance...

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Bibliographic Details
Main Authors:	Chen, L, Zeng, X, Kleibeuker, E, Buffa, F, Barberis, A, Leek, R, Roxanis, I, Zhang, W, Worth, A, Beech, J, Harris, A, Cai, S
Format:	Journal article
Language:	English
Published:	Impact Journals 2016

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