Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer

Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer

Clear cell renal cell carcinoma (ccRCC) is characterized by loss of function of the von Hippel-Lindau tumour suppressor (VHL) and unrestrained activation of hypoxia-inducible transcription factors (HIFs). Genetic and epigenetic determinants have an impact on HIF pathways. A recent genome-wide associ...

Descripció completa

Dades bibliogràfiques
Autors principals:	Grampp, S, Platt, J, Lauer, V, Salama, R, Kranz, F, Neumann, V, Wach, S, Stöhr, C, Hartmann, A, Eckardt, K, Ratcliffe, P, Mole, D, Schödel, J
Format:	Journal article
Idioma:	English
Publicat:	Nature Publishing Group 2016

Ítems similars

Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer
per: Steffen Grampp, et al.
Publicat: (2016-10-01)

Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway.
per: Grampp, S, et al.
Publicat: (2017)

Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway.
per: Steffen Grampp, et al.
Publicat: (2017-07-01)

Hypoxia drives glucose transporter 3 expression through HIF-mediated induction of the long non-coding RNA NICI
per: Lauer, V, et al.
Publicat: (2019)

Deciphering the 8q24.21 association for glioma.
per: Enciso-Mora, V, et al.
Publicat: (2013)

“Nosotros esperábamos…” (Lc 24,21)
per: Luis Heriberto Rivas
Publicat: (2016-12-01)

Association of 8q24.21 locus with the risk of colorectal cancer: A systematic review and meta-analysis
per: Haerian, M.S., et al.
Publicat: (2011)

2421
per: Jonathan N. Tobin, et al.
Publicat: (2017-09-01)

Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2.
per: Choudhry, H, et al.
Publicat: (2014)

Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2
per: Choudhry, H, et al.
Publicat: (2013)

Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression
per: Schödel, J, et al.
Publicat: (2012)

Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression.
per: Schödel, J, et al.
Publicat: (2012)

Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression
per: Schödel, J, et al.
Publicat: (2012)

Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation
per: Gyda Bjornsdottir, et al.
Publicat: (2017-02-01)

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq.
per: Schödel, J, et al.
Publicat: (2011)

Inherent DNA‐binding specificities of the HIF‐1α and HIF‐2α transcription factors in chromatin
per: Smythies, J, et al.
Publicat: (2018)

Regulation of HIF: prolyl hydroxylases.
per: Stolze, I, et al.
Publicat: (2006)

Capture-C reveals preformed chromatin interactions between HIF-binding sites and distant promoters
per: Platt, J, et al.
Publicat: (2016)

Capture‐C reveals preformed chromatin interactions between HIF‐binding sites and distant promoters
per: Platt, J, et al.
Publicat: (2016)

Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21
per: Quinn T. Ostrom, et al.
Publicat: (2018-05-01)

GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21
per: Joseph L. Wiemels, et al.
Publicat: (2018-01-01)

A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21.
per: Tomlinson, I, et al.
Publicat: (2007)

Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
per: Chan, M, et al.
Publicat: (2016)

PERTUMBUHAN CANDIDA ALBICANS PADA PERMUKAAN POLIESTER EBP-2421
per: Widowati Siswomihardjo
Publicat: (2015-08-01)

Pan-genomic binding of hypoxia-inducible transcription factors.
per: Schödel, J, et al.
Publicat: (2013)

Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21.
per: Zhang, M, et al.
Publicat: (2016)

Molecular and Functional Characterisation of a Novel Intragenic 12q24.21 Deletion Resulting in <i>MED13L</i> Haploinsufficiency Syndrome
per: Evelina Siavrienė, et al.
Publicat: (2023-06-01)

The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1.
per: Schietke, R, et al.
Publicat: (2010)

2421 Development and validation of a translational rat model of neonatal abstinence syndrome
per: Lisa Brents, et al.
Publicat: (2018-06-01)

Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation.
per: Tian, Y, et al.
Publicat: (2006)

Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing.
per: Mole, D, et al.
Publicat: (2001)

Multi-level interaction between HIF and AHR transcriptional pathways in kidney carcinoma
per: Lafleur, VN, et al.
Publicat: (2023)

Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1α (HIF1A) and result in differential HIF1A-dependent gene expression
per: Jantsch, J, et al.
Publicat: (2011)

Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1α (HIF1A) and result in differential HIF1A-dependent gene expression.
per: Jantsch, J, et al.
Publicat: (2011)

Co-incidence of RCC-susceptibility polymorphisms with HIF cis-acting sequences supports a pathway tuning model of cancer
per: Schmid, V, et al.
Publicat: (2019)

HIF-1 and HIF-2: working alone or together in hypoxia?
per: Ratcliffe, P
Publicat: (2007)

Determination and comparison of specific activity of the HIF-prolyl hydroxylases.
per: Tuckerman, JR, et al.
Publicat: (2004)

Dissecting transcription of the 8q24-MYC locus in prostate cancer recognizes the equilibration between androgen receptor direct and indirect dual-functions
per: Ju Guo, et al.
Publicat: (2023-10-01)

Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts.
per: Mole, D, et al.
Publicat: (2009)

HIF and MYC signaling in adrenal neoplasms of the neural crest: implications for pediatrics
per: Nicole Bechmann, et al.
Publicat: (2023-06-01)