Myh deficiency enhances intestinal tumorigenesis in multiple intestinal neoplasia (ApcMin/+) mice.

Monoallelic APC and biallelic MYH (homolog of Escherichia coli mutY) germ-line mutations are independently associated with a strong predisposition to colorectal adenomas and carcinoma in humans. Whereas mice heterozygous for mutant Apc develop intestinal tumors, mice homozygous for mutant Myh do not...

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Detalles Bibliográficos
Main Authors:	Sieber, O, Howarth, K, Thirlwell, C, Rowan, A, Mandir, N, Goodlad, R, Gilkar, A, Spencer-Dene, B, Stamp, G, Johnson, V, Silver, A, Yang, H, Miller, J, Ilyas, M, Tomlinson, I
Formato:	Journal article
Idioma:	English
Publicado:	2004

Myh deficiency enhances intestinal tumorigenesis in multiple intestinal neoplasia (ApcMin/+) mice.

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