The challenge of enteric fever.
Enteric fever, a non-specific, systemic infection caused by S. Typhi or Paratyphi A, B or C, is common in resource-limited regions of the world, where poor sanitation infrastructure facilitates faeco-oral transmission. Prompt treatment with appropriate antibiotics minimises illness severity, but pre...
| Main Authors: | , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2014
|
| _version_ | 1797085942445506560 |
|---|---|
| author | Waddington, C Darton, T Pollard, A |
| author_facet | Waddington, C Darton, T Pollard, A |
| author_sort | Waddington, C |
| collection | OXFORD |
| description | Enteric fever, a non-specific, systemic infection caused by S. Typhi or Paratyphi A, B or C, is common in resource-limited regions of the world, where poor sanitation infrastructure facilitates faeco-oral transmission. Prompt treatment with appropriate antibiotics minimises illness severity, but presentation to health care facilities is often delayed because of the non-specific nature of the symptoms and the lack of reliable diagnostic tests. Disease prevention requires significant investment in provision of clean water and sanitation in the long term; vaccination offers a more realistic strategy for medium term control. However, implementation of existing vaccines and development of more efficacious vaccines has been hindered by the lack of an established correlate of protection and under appreciation of the true disease burden. Human microbial infection studies could provide a vehicle for the rapid evaluation of novel vaccines and investigation of the immunobiology of enteric infection. |
| first_indexed | 2024-03-07T02:15:00Z |
| format | Journal article |
| id | oxford-uuid:a1eb9694-29c6-44bb-bc2c-de8ccb9dfc53 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:15:00Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:a1eb9694-29c6-44bb-bc2c-de8ccb9dfc532022-03-27T02:16:42ZThe challenge of enteric fever.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a1eb9694-29c6-44bb-bc2c-de8ccb9dfc53EnglishSymplectic Elements at Oxford2014Waddington, CDarton, TPollard, AEnteric fever, a non-specific, systemic infection caused by S. Typhi or Paratyphi A, B or C, is common in resource-limited regions of the world, where poor sanitation infrastructure facilitates faeco-oral transmission. Prompt treatment with appropriate antibiotics minimises illness severity, but presentation to health care facilities is often delayed because of the non-specific nature of the symptoms and the lack of reliable diagnostic tests. Disease prevention requires significant investment in provision of clean water and sanitation in the long term; vaccination offers a more realistic strategy for medium term control. However, implementation of existing vaccines and development of more efficacious vaccines has been hindered by the lack of an established correlate of protection and under appreciation of the true disease burden. Human microbial infection studies could provide a vehicle for the rapid evaluation of novel vaccines and investigation of the immunobiology of enteric infection. |
| spellingShingle | Waddington, C Darton, T Pollard, A The challenge of enteric fever. |
| title | The challenge of enteric fever. |
| title_full | The challenge of enteric fever. |
| title_fullStr | The challenge of enteric fever. |
| title_full_unstemmed | The challenge of enteric fever. |
| title_short | The challenge of enteric fever. |
| title_sort | challenge of enteric fever |
| work_keys_str_mv | AT waddingtonc thechallengeofentericfever AT dartont thechallengeofentericfever AT pollarda thechallengeofentericfever AT waddingtonc challengeofentericfever AT dartont challengeofentericfever AT pollarda challengeofentericfever |