Synthetic peptides that inhibit binding of the collagen type II 261-273 epitope to rheumatoid arthritis-associated HLA-DR1 and -DR4 molecules and collagen-specific T-cell responses.
Copolymer 1 [Cop 1, poly (Y, E, A, K)] is a random synthetic amino acid copolymer effective in the treatment of relapsing forms of multiple sclerosis (MS), a disease that is linked to HLA-DR2 (DRB1*1501). Another copolymer [poly (Y, A, K)] was also identified that binds to rheumatoid arthritis (RA)-...
| Main Authors: | , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2000
|
| _version_ | 1797085945285050368 |
|---|---|
| author | Fridkis-Hareli, M Rosloniec, E Fugger, L Strominger, J |
| author_facet | Fridkis-Hareli, M Rosloniec, E Fugger, L Strominger, J |
| author_sort | Fridkis-Hareli, M |
| collection | OXFORD |
| description | Copolymer 1 [Cop 1, poly (Y, E, A, K)] is a random synthetic amino acid copolymer effective in the treatment of relapsing forms of multiple sclerosis (MS), a disease that is linked to HLA-DR2 (DRB1*1501). Another copolymer [poly (Y, A, K)] was also identified that binds to rheumatoid arthritis (RA)-associated HLA-DR1 (DRB1*0101) or HLA-DR4 (DRB1*0401) molecules and inhibits the response of HLA-DR1- and -DR4-restricted T cell clones to an immunodominant epitope of collagen type II (CII) 261-273 (a candidate autoantigen in RA). In the present study various peptides have been synthesized based on binding "motifs" of Cop 1 for HLA-DR1 and -DR4 molecules. Those peptides with K at P-1 or K at P8 were particularly effective as inhibitors of binding of CII 261-273, of Cop 1 and of the influenza virus hemagglutinin peptide 306-318 to these class II proteins. Moreover, several of them were also potent inhibitors of the CII 261-273-reactive T cell clones. These findings suggest that small peptides or their more stable derivatives may be able to substitute for copolymers in the treatment of RA, and by implication of MS. |
| first_indexed | 2024-03-07T02:15:03Z |
| format | Journal article |
| id | oxford-uuid:a1ee2db9-34c0-4ade-828c-889dbaa83ac5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:15:03Z |
| publishDate | 2000 |
| record_format | dspace |
| spelling | oxford-uuid:a1ee2db9-34c0-4ade-828c-889dbaa83ac52022-03-27T02:16:42ZSynthetic peptides that inhibit binding of the collagen type II 261-273 epitope to rheumatoid arthritis-associated HLA-DR1 and -DR4 molecules and collagen-specific T-cell responses.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a1ee2db9-34c0-4ade-828c-889dbaa83ac5EnglishSymplectic Elements at Oxford2000Fridkis-Hareli, MRosloniec, EFugger, LStrominger, JCopolymer 1 [Cop 1, poly (Y, E, A, K)] is a random synthetic amino acid copolymer effective in the treatment of relapsing forms of multiple sclerosis (MS), a disease that is linked to HLA-DR2 (DRB1*1501). Another copolymer [poly (Y, A, K)] was also identified that binds to rheumatoid arthritis (RA)-associated HLA-DR1 (DRB1*0101) or HLA-DR4 (DRB1*0401) molecules and inhibits the response of HLA-DR1- and -DR4-restricted T cell clones to an immunodominant epitope of collagen type II (CII) 261-273 (a candidate autoantigen in RA). In the present study various peptides have been synthesized based on binding "motifs" of Cop 1 for HLA-DR1 and -DR4 molecules. Those peptides with K at P-1 or K at P8 were particularly effective as inhibitors of binding of CII 261-273, of Cop 1 and of the influenza virus hemagglutinin peptide 306-318 to these class II proteins. Moreover, several of them were also potent inhibitors of the CII 261-273-reactive T cell clones. These findings suggest that small peptides or their more stable derivatives may be able to substitute for copolymers in the treatment of RA, and by implication of MS. |
| spellingShingle | Fridkis-Hareli, M Rosloniec, E Fugger, L Strominger, J Synthetic peptides that inhibit binding of the collagen type II 261-273 epitope to rheumatoid arthritis-associated HLA-DR1 and -DR4 molecules and collagen-specific T-cell responses. |
| title | Synthetic peptides that inhibit binding of the collagen type II 261-273 epitope to rheumatoid arthritis-associated HLA-DR1 and -DR4 molecules and collagen-specific T-cell responses. |
| title_full | Synthetic peptides that inhibit binding of the collagen type II 261-273 epitope to rheumatoid arthritis-associated HLA-DR1 and -DR4 molecules and collagen-specific T-cell responses. |
| title_fullStr | Synthetic peptides that inhibit binding of the collagen type II 261-273 epitope to rheumatoid arthritis-associated HLA-DR1 and -DR4 molecules and collagen-specific T-cell responses. |
| title_full_unstemmed | Synthetic peptides that inhibit binding of the collagen type II 261-273 epitope to rheumatoid arthritis-associated HLA-DR1 and -DR4 molecules and collagen-specific T-cell responses. |
| title_short | Synthetic peptides that inhibit binding of the collagen type II 261-273 epitope to rheumatoid arthritis-associated HLA-DR1 and -DR4 molecules and collagen-specific T-cell responses. |
| title_sort | synthetic peptides that inhibit binding of the collagen type ii 261 273 epitope to rheumatoid arthritis associated hla dr1 and dr4 molecules and collagen specific t cell responses |
| work_keys_str_mv | AT fridkisharelim syntheticpeptidesthatinhibitbindingofthecollagentypeii261273epitopetorheumatoidarthritisassociatedhladr1anddr4moleculesandcollagenspecifictcellresponses AT rosloniece syntheticpeptidesthatinhibitbindingofthecollagentypeii261273epitopetorheumatoidarthritisassociatedhladr1anddr4moleculesandcollagenspecifictcellresponses AT fuggerl syntheticpeptidesthatinhibitbindingofthecollagentypeii261273epitopetorheumatoidarthritisassociatedhladr1anddr4moleculesandcollagenspecifictcellresponses AT stromingerj syntheticpeptidesthatinhibitbindingofthecollagentypeii261273epitopetorheumatoidarthritisassociatedhladr1anddr4moleculesandcollagenspecifictcellresponses |