Impact of vaccination on the association of COVID-19 with cardiovascular diseases: An OpenSAFELY cohort study
Infection with SARS-CoV-2 is associated with an increased risk of arterial and venous thrombotic events, but the implications of vaccination for this increased risk are uncertain. With the approval of NHS England, we quantified associations between COVID-19 diagnosis and cardiovascular diseases in d...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Nature Research
2024
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| _version_ | 1811139526372884480 |
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| author | Cezard, GI Denholm, RE Knight, R Wei, Y Teece, L Toms, R Forbes, HJ Walker, AJ Fisher, L Massey, J Hopcroft, LEM Horne, EMF Taylor, K Palmer, T Arab, MA Cuitun Coronado, JI Ip, SHY Davy, S Dillingham, I Bacon, S Mehrkar, A Morton, CE Greaves, F Hyams, C Goldacre, B |
| author_facet | Cezard, GI Denholm, RE Knight, R Wei, Y Teece, L Toms, R Forbes, HJ Walker, AJ Fisher, L Massey, J Hopcroft, LEM Horne, EMF Taylor, K Palmer, T Arab, MA Cuitun Coronado, JI Ip, SHY Davy, S Dillingham, I Bacon, S Mehrkar, A Morton, CE Greaves, F Hyams, C Goldacre, B |
| author_sort | Cezard, GI |
| collection | OXFORD |
| description | Infection with SARS-CoV-2 is associated with an increased risk of arterial and venous thrombotic events, but the implications of vaccination for this increased risk are uncertain. With the approval of NHS England, we quantified associations between COVID-19 diagnosis and cardiovascular diseases in different vaccination and variant eras using linked electronic health records for ~40% of the English population. We defined a ‘pre-vaccination’ cohort (18,210,937 people) in the wild-type/Alpha variant eras (January 2020-June 2021), and ‘vaccinated’ and ‘unvaccinated’ cohorts (13,572,399 and 3,161,485 people respectively) in the Delta variant era (June-December 2021). We showed that the incidence of each arterial thrombotic, venous thrombotic and other cardiovascular outcomes was substantially elevated during weeks 1-4 after COVID-19, compared with before or without COVID-19, but less markedly elevated in time periods beyond week 4. Hazard ratios were higher after hospitalised than non-hospitalised COVID-19 and higher in the pre-vaccination and unvaccinated cohorts than the vaccinated cohort. COVID-19 vaccination reduces the risk of cardiovascular events after COVID-19 infection. People who had COVID-19 before or without being vaccinated are at higher risk of cardiovascular events for at least two years. |
| first_indexed | 2024-09-25T04:07:29Z |
| format | Journal article |
| id | oxford-uuid:a224426b-beac-4ea5-9ead-566c4ffc9fa4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:07:29Z |
| publishDate | 2024 |
| publisher | Nature Research |
| record_format | dspace |
| spelling | oxford-uuid:a224426b-beac-4ea5-9ead-566c4ffc9fa42024-05-30T10:49:14ZImpact of vaccination on the association of COVID-19 with cardiovascular diseases: An OpenSAFELY cohort studyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a224426b-beac-4ea5-9ead-566c4ffc9fa4EnglishJisc Publications RouterNature Research2024Cezard, GIDenholm, REKnight, RWei, YTeece, LToms, RForbes, HJWalker, AJFisher, LMassey, JHopcroft, LEMHorne, EMFTaylor, KPalmer, TArab, MACuitun Coronado, JIIp, SHYDavy, SDillingham, IBacon, SMehrkar, AMorton, CEGreaves, FHyams, CGoldacre, BInfection with SARS-CoV-2 is associated with an increased risk of arterial and venous thrombotic events, but the implications of vaccination for this increased risk are uncertain. With the approval of NHS England, we quantified associations between COVID-19 diagnosis and cardiovascular diseases in different vaccination and variant eras using linked electronic health records for ~40% of the English population. We defined a ‘pre-vaccination’ cohort (18,210,937 people) in the wild-type/Alpha variant eras (January 2020-June 2021), and ‘vaccinated’ and ‘unvaccinated’ cohorts (13,572,399 and 3,161,485 people respectively) in the Delta variant era (June-December 2021). We showed that the incidence of each arterial thrombotic, venous thrombotic and other cardiovascular outcomes was substantially elevated during weeks 1-4 after COVID-19, compared with before or without COVID-19, but less markedly elevated in time periods beyond week 4. Hazard ratios were higher after hospitalised than non-hospitalised COVID-19 and higher in the pre-vaccination and unvaccinated cohorts than the vaccinated cohort. COVID-19 vaccination reduces the risk of cardiovascular events after COVID-19 infection. People who had COVID-19 before or without being vaccinated are at higher risk of cardiovascular events for at least two years. |
| spellingShingle | Cezard, GI Denholm, RE Knight, R Wei, Y Teece, L Toms, R Forbes, HJ Walker, AJ Fisher, L Massey, J Hopcroft, LEM Horne, EMF Taylor, K Palmer, T Arab, MA Cuitun Coronado, JI Ip, SHY Davy, S Dillingham, I Bacon, S Mehrkar, A Morton, CE Greaves, F Hyams, C Goldacre, B Impact of vaccination on the association of COVID-19 with cardiovascular diseases: An OpenSAFELY cohort study |
| title | Impact of vaccination on the association of COVID-19 with cardiovascular diseases: An OpenSAFELY cohort study |
| title_full | Impact of vaccination on the association of COVID-19 with cardiovascular diseases: An OpenSAFELY cohort study |
| title_fullStr | Impact of vaccination on the association of COVID-19 with cardiovascular diseases: An OpenSAFELY cohort study |
| title_full_unstemmed | Impact of vaccination on the association of COVID-19 with cardiovascular diseases: An OpenSAFELY cohort study |
| title_short | Impact of vaccination on the association of COVID-19 with cardiovascular diseases: An OpenSAFELY cohort study |
| title_sort | impact of vaccination on the association of covid 19 with cardiovascular diseases an opensafely cohort study |
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