Diminished brain 5-HT transporter binding in major depression: a positron emission tomography study with [11C]DASB.
BACKGROUND: The serotonin transporter (5-HTT) plays a critical role in the regulation of serotonin neurotransmission and has been implicated in the pathophysiology of major depression. In a previous positron emission tomography study, we found no difference in brain 5-HTT binding between unmedicated...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2011
|
| _version_ | 1797085995477237760 |
|---|---|
| author | Selvaraj, S Murthy, N Bhagwagar, Z Bose, S Hinz, R Grasby, P Cowen, P |
| author_facet | Selvaraj, S Murthy, N Bhagwagar, Z Bose, S Hinz, R Grasby, P Cowen, P |
| author_sort | Selvaraj, S |
| collection | OXFORD |
| description | BACKGROUND: The serotonin transporter (5-HTT) plays a critical role in the regulation of serotonin neurotransmission and has been implicated in the pathophysiology of major depression. In a previous positron emission tomography study, we found no difference in brain 5-HTT binding between unmedicated recovered depressed patients and healthy controls. AIM: This study aims to assess brain 5-HTT binding in a group of unmedicated acutely depressed patients in comparison to healthy controls. METHODS: We studied 5-HTT binding using [(11)C]DASB in conjunction with positron emission tomography in 12 medication-free depressed patients with a mean duration of illness of about 1 year and 24 healthy controls. RESULTS: The depressed patients had lowered 5-HTT binding in several brain regions including brain stem, thalamus, caudate, putamen, anterior cingulate cortex and frontal cortex. CONCLUSIONS: These results suggest that diminished availability of the 5-HTT in the brain may be a state marker of acute depression. Alternatively, low 5-HTT binding may delineate a group of depressed patients with a poor long-term prognosis. |
| first_indexed | 2024-03-07T02:15:43Z |
| format | Journal article |
| id | oxford-uuid:a22b5ae5-35c7-42d3-a6ee-609be989cf0d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:15:43Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:a22b5ae5-35c7-42d3-a6ee-609be989cf0d2022-03-27T02:18:18ZDiminished brain 5-HT transporter binding in major depression: a positron emission tomography study with [11C]DASB.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a22b5ae5-35c7-42d3-a6ee-609be989cf0dEnglishSymplectic Elements at Oxford2011Selvaraj, SMurthy, NBhagwagar, ZBose, SHinz, RGrasby, PCowen, PBACKGROUND: The serotonin transporter (5-HTT) plays a critical role in the regulation of serotonin neurotransmission and has been implicated in the pathophysiology of major depression. In a previous positron emission tomography study, we found no difference in brain 5-HTT binding between unmedicated recovered depressed patients and healthy controls. AIM: This study aims to assess brain 5-HTT binding in a group of unmedicated acutely depressed patients in comparison to healthy controls. METHODS: We studied 5-HTT binding using [(11)C]DASB in conjunction with positron emission tomography in 12 medication-free depressed patients with a mean duration of illness of about 1 year and 24 healthy controls. RESULTS: The depressed patients had lowered 5-HTT binding in several brain regions including brain stem, thalamus, caudate, putamen, anterior cingulate cortex and frontal cortex. CONCLUSIONS: These results suggest that diminished availability of the 5-HTT in the brain may be a state marker of acute depression. Alternatively, low 5-HTT binding may delineate a group of depressed patients with a poor long-term prognosis. |
| spellingShingle | Selvaraj, S Murthy, N Bhagwagar, Z Bose, S Hinz, R Grasby, P Cowen, P Diminished brain 5-HT transporter binding in major depression: a positron emission tomography study with [11C]DASB. |
| title | Diminished brain 5-HT transporter binding in major depression: a positron emission tomography study with [11C]DASB. |
| title_full | Diminished brain 5-HT transporter binding in major depression: a positron emission tomography study with [11C]DASB. |
| title_fullStr | Diminished brain 5-HT transporter binding in major depression: a positron emission tomography study with [11C]DASB. |
| title_full_unstemmed | Diminished brain 5-HT transporter binding in major depression: a positron emission tomography study with [11C]DASB. |
| title_short | Diminished brain 5-HT transporter binding in major depression: a positron emission tomography study with [11C]DASB. |
| title_sort | diminished brain 5 ht transporter binding in major depression a positron emission tomography study with 11c dasb |
| work_keys_str_mv | AT selvarajs diminishedbrain5httransporterbindinginmajordepressionapositronemissiontomographystudywith11cdasb AT murthyn diminishedbrain5httransporterbindinginmajordepressionapositronemissiontomographystudywith11cdasb AT bhagwagarz diminishedbrain5httransporterbindinginmajordepressionapositronemissiontomographystudywith11cdasb AT boses diminishedbrain5httransporterbindinginmajordepressionapositronemissiontomographystudywith11cdasb AT hinzr diminishedbrain5httransporterbindinginmajordepressionapositronemissiontomographystudywith11cdasb AT grasbyp diminishedbrain5httransporterbindinginmajordepressionapositronemissiontomographystudywith11cdasb AT cowenp diminishedbrain5httransporterbindinginmajordepressionapositronemissiontomographystudywith11cdasb |