Genome-wide association studies of global Mycobacterium tuberculosis resistance to 13 antimicrobials in 10,228 genomes identify new resistance mechanisms

The emergence of drug-resistant tuberculosis is a major global public health concern that threatens the ability to control the disease. Whole-genome sequencing as a tool to rapidly diagnose resistant infections can transform patient treatment and clinical practice. While resistance mechanisms are we...

Full description

Bibliographic Details
Main Authors: Earle, SG, Wilson, DJ, Barilar, I, Battaglia, S, Cirillo, DM, Clifton, DA, Crook, DW, Fowler, PW, Grazian, C, Hunt, M, Iqbal, Z, Ismail, NA, Knaggs, J, Lachapelle, AS, Merker, M, Mistry, N, Moore, D, Niemann, S, Peto, TEA, Rodrigues, C, Thwaites, G, Walker, AS
Other Authors: CRyPTIC Consortium
Format: Journal article
Language:English
Published: Public Library of Science 2022