Lipid interactions of a ciliary membrane TRP channel: simulation and structural studies of Polycystin-2 (PC2)

Lipid interactions of a ciliary membrane TRP channel: simulation and structural studies of Polycystin-2 (PC2)

Polycystin-2 (PC2) is a transient receptor potential (TRP) channel present in ciliary membranes of the kidney. PC2 shares a transmembrane fold with other TRP channels, in addition to an extracellular domain found in TRPP and TRPML channels. Using molecular dynamics (MD) simulations and cryoelectron...

Fuld beskrivelse

Bibliografiske detaljer
Main Authors:	Wang, Q, Corey, R, Hedger, G, Aryal, P, Grieben, M, Nasrallah, C, Baronina, A, Pike, A, Shi, J, Carpenter, E, Sansom, M
Format:	Journal article
Sprog:	English
Udgivet:	Cell Press 2019

Lignende værker

Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)
af: Grieben, M, et al.
Udgivet: (2016)

Molecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2.
af: Wilkes, M, et al.
Udgivet: (2017)

A polycystin-type transient receptor potential (Trp) channel that is activated by ATP
af: David Traynor, et al.
Udgivet: (2017-02-01)

Lipid bilayer-atomic force microscopy combined platform records simultaneous electrical and topological changes of the TRP channel polycystin-2 (TRPP2).
af: Sumit Lal, et al.
Udgivet: (2018-01-01)

Investigating the role of ciliary localisation of the TRPP Channel, Polycystin2 (PKD2), on development and progression of polycystic kidney disease
af: Walker, R
Udgivet: (2016)

The heteromeric PC-1/PC-2 polycystin complex is activated by the PC-1 N-terminus
af: Kotdaji Ha, et al.
Udgivet: (2020-11-01)

Polycystin-1 Interacting Protein-1 (CU062) Interacts with the Ectodomain of Polycystin-1 (PC1)
af: Wendy A. Lea, et al.
Udgivet: (2023-08-01)

Ciliary exclusion of Polycystin-2 promotes kidney cystogenesis in an autosomal dominant polycystic kidney disease model
af: Rebecca V. Walker, et al.
Udgivet: (2019-09-01)

Anoctamin 1 Inhibition Suppresses Cystogenesis by Enhancing Ciliogenesis and the Ciliary Dosage of Polycystins
af: Tao Xu, et al.
Udgivet: (2022-07-01)

A plasma membrane-localized polycystin-1/polycystin-2 complex in endothelial cells elicits vasodilation
af: Charles E MacKay, et al.
Udgivet: (2022-03-01)

Cryo-EM structure of the polycystin 2-l1 ion channel
af: Raymond E Hulse, et al.
Udgivet: (2018-07-01)

Atypical calcium regulation of the PKD2-L1 polycystin ion channel
af: Paul G DeCaen, et al.
Udgivet: (2016-06-01)

Lipid interaction sites on channels, transporters and receptors: recent insights from molecular dynamics simulations
af: Sansom, M, et al.
Udgivet: (2016)

A synthetic method to assay polycystin channel biophysics
af: Megan Larmore, et al.
Udgivet: (2024-10-01)

TRP channels /
af: Zhu, Michael X. 524478
Udgivet: (2011)

Understanding the structure and interactions of polycystin-2 through structural and simulation studies
af: Wang, Q
Udgivet: (2019)

OFD1 and flotillins are integral components of a ciliary signaling protein complex organized by polycystins in renal epithelia and odontoblasts.
af: Stephanie Jerman, et al.
Udgivet: (2014-01-01)

Intravascular flow stimulates PKD2 (polycystin-2) channels in endothelial cells to reduce blood pressure
af: Charles E MacKay, et al.
Udgivet: (2020-05-01)

The Role of Membrane Lipids in Light-Activation of <i>Drosophila</i> TRP Channels
af: Rita Gutorov, et al.
Udgivet: (2022-02-01)

TRP-channels as key integrators of lipid pathways in nociceptive neurons.
af: Sisignano, M, et al.
Udgivet: (2014)

Sensory TRP Channel Interactions with Endogenous Lipids and Their Biological Outcomes
af: Sungjae Yoo, et al.
Udgivet: (2014-04-01)

Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium
af: Xiaowen Liu, et al.
Udgivet: (2018-02-01)

Filamin-a increases the stability and plasma membrane expression of polycystin-2.
af: Qian Wang, et al.
Udgivet: (2015-01-01)

Structural interaction and functional regulation of polycystin-2 by filamin.
af: Qian Wang, et al.
Udgivet: (2012-01-01)

Intracellular calcium release modulates polycystin-2 trafficking
af: Miyakawa Ayako, et al.
Udgivet: (2013-02-01)

Correction: Intravascular flow stimulates PKD2 (polycystin-2) channels in endothelial cells to reduce blood pressure
af: Charles E MacKay, et al.
Udgivet: (2020-06-01)

TRP channels in schistosomes
af: Swarna Bais, et al.
Udgivet: (2016-12-01)

Mechanoprotection by Polycystins against Apoptosis Is Mediated through the Opening of Stretch-Activated K2P Channels
af: Rémi Peyronnet, et al.
Udgivet: (2012-03-01)

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac
af: Dong, Y, et al.
Udgivet: (2015)

Vasoregression linked to neuronal damage in the rat with defect of polycystin-2.
af: Yuxi Feng, et al.
Udgivet: (2009-10-01)

The Gating of Polycystin Signaling Complex
af: PATRICK DELMAS
Udgivet: (2004-01-01)

Polycystins, ADPKD, and Cardiovascular Disease
af: Ivana Y. Kuo, et al.
Udgivet: (2020-04-01)

Defining how multiple lipid species interact with inward rectifier potassium (Kir2) channels
af: Duncan, AL, et al.
Udgivet: (2020)

TRP Channels in Human Prostate
af: Carl Van Haute, et al.
Udgivet: (2010-01-01)

Trafficking of ThermoTRP Channels
af: Clotilde Ferrandiz-Huertas, et al.
Udgivet: (2014-08-01)

Schistosome TRP channels: An appraisal
af: Swarna Bais, et al.
Udgivet: (2020-08-01)

Renal vascular TRP channels
af: Praghalathan Kanthakumar, et al.
Udgivet: (2021-01-01)

Diethylcarbamazine, TRP channels and Ca2+ signaling in cells of the Ascaris intestine
af: Paul D. E. Williams, et al.
Udgivet: (2022-12-01)

Exquisite sensitivity of Polycystin-1 to H2O2 concentration in the endoplasmic reticulum
af: Elisa Speranza, et al.
Udgivet: (2025-03-01)

Heteromeric TRP Channels in Lung Inflammation
af: Meryam Zergane, et al.
Udgivet: (2021-07-01)