Lipid interactions of a ciliary membrane TRP channel: simulation and structural studies of Polycystin-2 (PC2)

Lipid interactions of a ciliary membrane TRP channel: simulation and structural studies of Polycystin-2 (PC2)

Polycystin-2 (PC2) is a transient receptor potential (TRP) channel present in ciliary membranes of the kidney. PC2 shares a transmembrane fold with other TRP channels, in addition to an extracellular domain found in TRPP and TRPML channels. Using molecular dynamics (MD) simulations and cryoelectron...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Wang, Q, Corey, R, Hedger, G, Aryal, P, Grieben, M, Nasrallah, C, Baronina, A, Pike, A, Shi, J, Carpenter, E, Sansom, M
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	Cell Press 2019

Παρόμοια τεκμήρια

Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)
ανά: Grieben, M, κ.ά.
Έκδοση: (2016)

Molecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2.
ανά: Wilkes, M, κ.ά.
Έκδοση: (2017)

A polycystin-type transient receptor potential (Trp) channel that is activated by ATP
ανά: David Traynor, κ.ά.
Έκδοση: (2017-02-01)

Lipid bilayer-atomic force microscopy combined platform records simultaneous electrical and topological changes of the TRP channel polycystin-2 (TRPP2).
ανά: Sumit Lal, κ.ά.
Έκδοση: (2018-01-01)

Investigating the role of ciliary localisation of the TRPP Channel, Polycystin2 (PKD2), on development and progression of polycystic kidney disease
ανά: Walker, R
Έκδοση: (2016)

The heteromeric PC-1/PC-2 polycystin complex is activated by the PC-1 N-terminus
ανά: Kotdaji Ha, κ.ά.
Έκδοση: (2020-11-01)

Polycystin-1 Interacting Protein-1 (CU062) Interacts with the Ectodomain of Polycystin-1 (PC1)
ανά: Wendy A. Lea, κ.ά.
Έκδοση: (2023-08-01)

Ciliary exclusion of Polycystin-2 promotes kidney cystogenesis in an autosomal dominant polycystic kidney disease model
ανά: Rebecca V. Walker, κ.ά.
Έκδοση: (2019-09-01)

Anoctamin 1 Inhibition Suppresses Cystogenesis by Enhancing Ciliogenesis and the Ciliary Dosage of Polycystins
ανά: Tao Xu, κ.ά.
Έκδοση: (2022-07-01)

A plasma membrane-localized polycystin-1/polycystin-2 complex in endothelial cells elicits vasodilation
ανά: Charles E MacKay, κ.ά.
Έκδοση: (2022-03-01)

Cryo-EM structure of the polycystin 2-l1 ion channel
ανά: Raymond E Hulse, κ.ά.
Έκδοση: (2018-07-01)

Atypical calcium regulation of the PKD2-L1 polycystin ion channel
ανά: Paul G DeCaen, κ.ά.
Έκδοση: (2016-06-01)

Lipid interaction sites on channels, transporters and receptors: recent insights from molecular dynamics simulations
ανά: Sansom, M, κ.ά.
Έκδοση: (2016)

A synthetic method to assay polycystin channel biophysics
ανά: Megan Larmore, κ.ά.
Έκδοση: (2024-10-01)

TRP channels /
ανά: Zhu, Michael X. 524478
Έκδοση: (2011)

Understanding the structure and interactions of polycystin-2 through structural and simulation studies
ανά: Wang, Q
Έκδοση: (2019)

OFD1 and flotillins are integral components of a ciliary signaling protein complex organized by polycystins in renal epithelia and odontoblasts.
ανά: Stephanie Jerman, κ.ά.
Έκδοση: (2014-01-01)

Intravascular flow stimulates PKD2 (polycystin-2) channels in endothelial cells to reduce blood pressure
ανά: Charles E MacKay, κ.ά.
Έκδοση: (2020-05-01)

The Role of Membrane Lipids in Light-Activation of <i>Drosophila</i> TRP Channels
ανά: Rita Gutorov, κ.ά.
Έκδοση: (2022-02-01)

TRP-channels as key integrators of lipid pathways in nociceptive neurons.
ανά: Sisignano, M, κ.ά.
Έκδοση: (2014)

Sensory TRP Channel Interactions with Endogenous Lipids and Their Biological Outcomes
ανά: Sungjae Yoo, κ.ά.
Έκδοση: (2014-04-01)

Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium
ανά: Xiaowen Liu, κ.ά.
Έκδοση: (2018-02-01)

Filamin-a increases the stability and plasma membrane expression of polycystin-2.
ανά: Qian Wang, κ.ά.
Έκδοση: (2015-01-01)

Structural interaction and functional regulation of polycystin-2 by filamin.
ανά: Qian Wang, κ.ά.
Έκδοση: (2012-01-01)

Intracellular calcium release modulates polycystin-2 trafficking
ανά: Miyakawa Ayako, κ.ά.
Έκδοση: (2013-02-01)

Correction: Intravascular flow stimulates PKD2 (polycystin-2) channels in endothelial cells to reduce blood pressure
ανά: Charles E MacKay, κ.ά.
Έκδοση: (2020-06-01)

TRP channels in schistosomes
ανά: Swarna Bais, κ.ά.
Έκδοση: (2016-12-01)

Mechanoprotection by Polycystins against Apoptosis Is Mediated through the Opening of Stretch-Activated K2P Channels
ανά: Rémi Peyronnet, κ.ά.
Έκδοση: (2012-03-01)

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac
ανά: Dong, Y, κ.ά.
Έκδοση: (2015)

Vasoregression linked to neuronal damage in the rat with defect of polycystin-2.
ανά: Yuxi Feng, κ.ά.
Έκδοση: (2009-10-01)

The Gating of Polycystin Signaling Complex
ανά: PATRICK DELMAS
Έκδοση: (2004-01-01)

Polycystins, ADPKD, and Cardiovascular Disease
ανά: Ivana Y. Kuo, κ.ά.
Έκδοση: (2020-04-01)

Defining how multiple lipid species interact with inward rectifier potassium (Kir2) channels
ανά: Duncan, AL, κ.ά.
Έκδοση: (2020)

TRP Channels in Human Prostate
ανά: Carl Van Haute, κ.ά.
Έκδοση: (2010-01-01)

Trafficking of ThermoTRP Channels
ανά: Clotilde Ferrandiz-Huertas, κ.ά.
Έκδοση: (2014-08-01)

Schistosome TRP channels: An appraisal
ανά: Swarna Bais, κ.ά.
Έκδοση: (2020-08-01)

Renal vascular TRP channels
ανά: Praghalathan Kanthakumar, κ.ά.
Έκδοση: (2021-01-01)

Diethylcarbamazine, TRP channels and Ca2+ signaling in cells of the Ascaris intestine
ανά: Paul D. E. Williams, κ.ά.
Έκδοση: (2022-12-01)

Exquisite sensitivity of Polycystin-1 to H2O2 concentration in the endoplasmic reticulum
ανά: Elisa Speranza, κ.ά.
Έκδοση: (2025-03-01)

Heteromeric TRP Channels in Lung Inflammation
ανά: Meryam Zergane, κ.ά.
Έκδοση: (2021-07-01)