LINGO-1 is a New Therapy Target and Biomarker for Ewing Sarcoma
Ewing sarcoma is a predominantly paediatric cancer with a high rate of metastasis and reoccurrence. A new surface marker called LINGO-1 was recently identified on Ewing tumours as a potential target for antibody-mediated therapies. However, such targeting requires caution because of LINGO-1 expressi...
| Main Authors: | , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Remedy Publications LLC
2017
|
| _version_ | 1826288645803343872 |
|---|---|
| author | Jain, A Zhang, J Rabbitts, T |
| author_facet | Jain, A Zhang, J Rabbitts, T |
| author_sort | Jain, A |
| collection | OXFORD |
| description | Ewing sarcoma is a predominantly paediatric cancer with a high rate of metastasis and reoccurrence. A new surface marker called LINGO-1 was recently identified on Ewing tumours as a potential target for antibody-mediated therapies. However, such targeting requires caution because of LINGO-1 expression on some brain cells. Although the blood-brain-barrier exists, small amounts of antibody may cross this barrier and cause harmful side-effects. In this perspective, we suggest some options to alleviate this risk that can make targeting tumour cells expressing the LINGO-1 antigen a safe option. |
| first_indexed | 2024-03-07T02:16:51Z |
| format | Journal article |
| id | oxford-uuid:a28b73d6-9d41-4476-a9e8-dc90b94fb5c4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:16:51Z |
| publishDate | 2017 |
| publisher | Remedy Publications LLC |
| record_format | dspace |
| spelling | oxford-uuid:a28b73d6-9d41-4476-a9e8-dc90b94fb5c42022-03-27T02:20:52ZLINGO-1 is a New Therapy Target and Biomarker for Ewing SarcomaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a28b73d6-9d41-4476-a9e8-dc90b94fb5c4EnglishSymplectic Elements at OxfordRemedy Publications LLC2017Jain, AZhang, JRabbitts, TEwing sarcoma is a predominantly paediatric cancer with a high rate of metastasis and reoccurrence. A new surface marker called LINGO-1 was recently identified on Ewing tumours as a potential target for antibody-mediated therapies. However, such targeting requires caution because of LINGO-1 expression on some brain cells. Although the blood-brain-barrier exists, small amounts of antibody may cross this barrier and cause harmful side-effects. In this perspective, we suggest some options to alleviate this risk that can make targeting tumour cells expressing the LINGO-1 antigen a safe option. |
| spellingShingle | Jain, A Zhang, J Rabbitts, T LINGO-1 is a New Therapy Target and Biomarker for Ewing Sarcoma |
| title | LINGO-1 is a New Therapy Target and Biomarker for Ewing Sarcoma |
| title_full | LINGO-1 is a New Therapy Target and Biomarker for Ewing Sarcoma |
| title_fullStr | LINGO-1 is a New Therapy Target and Biomarker for Ewing Sarcoma |
| title_full_unstemmed | LINGO-1 is a New Therapy Target and Biomarker for Ewing Sarcoma |
| title_short | LINGO-1 is a New Therapy Target and Biomarker for Ewing Sarcoma |
| title_sort | lingo 1 is a new therapy target and biomarker for ewing sarcoma |
| work_keys_str_mv | AT jaina lingo1isanewtherapytargetandbiomarkerforewingsarcoma AT zhangj lingo1isanewtherapytargetandbiomarkerforewingsarcoma AT rabbittst lingo1isanewtherapytargetandbiomarkerforewingsarcoma |