Triggering of the high-affinity IgE receptor in an aggregation-independent manner

The high-affinity IgE receptor, FcεR1, is responsible for the sensitization of mast cells and basophils to IgE-targeted anti- gens. The current model of FcεR1 triggering rests on the principle of aggregation-driven phosphorylation, yet several recent observations have indicated that this is incomple...

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מידע ביבליוגרפי
Main Authors: Felce, J, Sezgin, E, Wane, M, Dustin, M, Eggeling, C, Davis, S
פורמט: Conference item
יצא לאור: Springer 2017
תיאור
סיכום:The high-affinity IgE receptor, FcεR1, is responsible for the sensitization of mast cells and basophils to IgE-targeted anti- gens. The current model of FcεR1 triggering rests on the principle of aggregation-driven phosphorylation, yet several recent observations have indicated that this is incomplete. Here we re-examine the minimal requirements for FcεR1 triggering and observe that it is induced without receptor aggregation by surface-associated antigen in a size-dependent manner.