The evolutionary landscape of colorectal tumorigenesis

The evolutionary landscape of colorectal tumorigenesis

The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant) remain largely undetermined. Using multi-region genome and exome sequencing of 24 benign and malignant colorectal tumours, we investigate the evolutionary fitness landscape occupied by these neoplas...

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Hlavní autoři: Cross, W, Kovac, M, Mustonen, V, Temko, D, Davis, H, Baker, A, Biswas, S, Arnold, R, Chegwidden, L, Gatenbee, C, Anderson, A, Koelzer, V, Martinez, P, Jiang, X, Domingo, E, Woodcock, D, Feng, Y, Kovacova, M, Maughan, T, S:Cort Consortium, Jansen, M, Rodriguez-Justo, M, Ashraf, S, Guy, R, Cunningham, C, East, J, Wedge, D, Wang, L, Palles, C, Heinimann, K, Sottoriva, A, Leedham, S, Graham, T, Tomlinson, I
Médium: Journal article
Jazyk:English
Vydáno: Springer Nature 2018

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