Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease.
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterised by the preferential loss of dopaminergic neurons in the substantia nigra. Mitochondrial dysfunction is increasingly appreciated as a key determinant of dopaminergic neuronal susceptibility in PD and is a feature...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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Elsevier
2015
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| _version_ | 1797086138454769664 |
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| author | Ryan, B Hoek, S Fon, E Wade-Martins, R |
| author_facet | Ryan, B Hoek, S Fon, E Wade-Martins, R |
| author_sort | Ryan, B |
| collection | OXFORD |
| description | Parkinson's disease (PD) is a progressive neurodegenerative disorder characterised by the preferential loss of dopaminergic neurons in the substantia nigra. Mitochondrial dysfunction is increasingly appreciated as a key determinant of dopaminergic neuronal susceptibility in PD and is a feature of both familial and sporadic disease, as well as in toxin-induced Parkinsonism. Recently, the mechanisms by which PD-associated mitochondrial proteins phosphatase and tensin homolog deleted on chromosome 10 (PTEN)-induced putative kinase 1 (PINK1) and parkin function and induce neurodegeneration have been identified. In addition, increasing evidence implicates other PD-associated proteins such as α-synuclein (α-syn) and leucine-rich repeat kinase 2 (LRRK2) in mitochondrial dysfunction in genetic cases of PD with the potential for a large functional overlap with sporadic disease. This review highlights how recent advances in understanding familial PD-associated proteins have identified novel mechanisms and therapeutic strategies for addressing mitochondrial dysfunction in PD. |
| first_indexed | 2024-03-07T02:17:47Z |
| format | Journal article |
| id | oxford-uuid:a2dbf60e-828b-4f62-b5a2-036776e2882c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:17:47Z |
| publishDate | 2015 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:a2dbf60e-828b-4f62-b5a2-036776e2882c2022-03-27T02:22:52ZMitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a2dbf60e-828b-4f62-b5a2-036776e2882cEnglishSymplectic Elements at OxfordElsevier2015Ryan, BHoek, SFon, EWade-Martins, RParkinson's disease (PD) is a progressive neurodegenerative disorder characterised by the preferential loss of dopaminergic neurons in the substantia nigra. Mitochondrial dysfunction is increasingly appreciated as a key determinant of dopaminergic neuronal susceptibility in PD and is a feature of both familial and sporadic disease, as well as in toxin-induced Parkinsonism. Recently, the mechanisms by which PD-associated mitochondrial proteins phosphatase and tensin homolog deleted on chromosome 10 (PTEN)-induced putative kinase 1 (PINK1) and parkin function and induce neurodegeneration have been identified. In addition, increasing evidence implicates other PD-associated proteins such as α-synuclein (α-syn) and leucine-rich repeat kinase 2 (LRRK2) in mitochondrial dysfunction in genetic cases of PD with the potential for a large functional overlap with sporadic disease. This review highlights how recent advances in understanding familial PD-associated proteins have identified novel mechanisms and therapeutic strategies for addressing mitochondrial dysfunction in PD. |
| spellingShingle | Ryan, B Hoek, S Fon, E Wade-Martins, R Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease. |
| title | Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease. |
| title_full | Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease. |
| title_fullStr | Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease. |
| title_full_unstemmed | Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease. |
| title_short | Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease. |
| title_sort | mitochondrial dysfunction and mitophagy in parkinson s from familial to sporadic disease |
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