Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease.

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterised by the preferential loss of dopaminergic neurons in the substantia nigra. Mitochondrial dysfunction is increasingly appreciated as a key determinant of dopaminergic neuronal susceptibility in PD and is a feature...

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Hlavní autoři: Ryan, B, Hoek, S, Fon, E, Wade-Martins, R
Médium: Journal article
Jazyk:English
Vydáno: Elsevier 2015