SPECT imaging and biodistribution studies of 111In-EGF-Au-PEG nanoparticles in vivo
Radiolabelled antibodies and peptides hold promise for molecular radiotherapy but are often limited by low payload resulting in delivery of inadequate amounts of radioactivity to tumour tissue and, therefore, modest therapeutic effect. We have developed PEGylated epidermal growth factor (EGF)-gold n...
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| Format: | Conference item |
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SpringerOpen
2016
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| _version_ | 1797086143725961216 |
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| author | Song, L Able, S Falzone, N Kersemans, V Vallis, K |
| author_facet | Song, L Able, S Falzone, N Kersemans, V Vallis, K |
| author_sort | Song, L |
| collection | OXFORD |
| description | Radiolabelled antibodies and peptides hold promise for molecular radiotherapy but are often limited by low payload resulting in delivery of inadequate amounts of radioactivity to tumour tissue and, therefore, modest therapeutic effect. We have developed PEGylated epidermal growth factor (EGF)-gold nanoparticles (NP) with a high indium-111 (<sup>111</sup>In) payload (<sup>111</sup>In-EGF-Au-PEG NPs) as a prototypic NP-based theranostic radiopharmaceutical. |
| first_indexed | 2024-03-07T02:17:52Z |
| format | Conference item |
| id | oxford-uuid:a2e2e8f8-4d8d-4e72-91f8-a28e8c519e67 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T02:17:52Z |
| publishDate | 2016 |
| publisher | SpringerOpen |
| record_format | dspace |
| spelling | oxford-uuid:a2e2e8f8-4d8d-4e72-91f8-a28e8c519e672022-03-27T02:23:01ZSPECT imaging and biodistribution studies of 111In-EGF-Au-PEG nanoparticles in vivoConference itemhttp://purl.org/coar/resource_type/c_5794uuid:a2e2e8f8-4d8d-4e72-91f8-a28e8c519e67Symplectic Elements at OxfordSpringerOpen2016Song, LAble, SFalzone, NKersemans, VVallis, KRadiolabelled antibodies and peptides hold promise for molecular radiotherapy but are often limited by low payload resulting in delivery of inadequate amounts of radioactivity to tumour tissue and, therefore, modest therapeutic effect. We have developed PEGylated epidermal growth factor (EGF)-gold nanoparticles (NP) with a high indium-111 (<sup>111</sup>In) payload (<sup>111</sup>In-EGF-Au-PEG NPs) as a prototypic NP-based theranostic radiopharmaceutical. |
| spellingShingle | Song, L Able, S Falzone, N Kersemans, V Vallis, K SPECT imaging and biodistribution studies of 111In-EGF-Au-PEG nanoparticles in vivo |
| title | SPECT imaging and biodistribution studies of 111In-EGF-Au-PEG nanoparticles in vivo |
| title_full | SPECT imaging and biodistribution studies of 111In-EGF-Au-PEG nanoparticles in vivo |
| title_fullStr | SPECT imaging and biodistribution studies of 111In-EGF-Au-PEG nanoparticles in vivo |
| title_full_unstemmed | SPECT imaging and biodistribution studies of 111In-EGF-Au-PEG nanoparticles in vivo |
| title_short | SPECT imaging and biodistribution studies of 111In-EGF-Au-PEG nanoparticles in vivo |
| title_sort | spect imaging and biodistribution studies of 111in egf au peg nanoparticles in vivo |
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