Effects of sodium‐glucose co‐transporter‐2 inhibitors in type 2 diabetes in women versus men
Sodium‐glucose co‐transporter‐2 (SGLT2) inhibitors prevent cardiovascular complications in type 2 diabetes. We aimed to study whether they have similar effects in women and men by summarizing the effects of SGLT2 inhibitors compared to placebo on vascular and safety outcomes stratified by sex. We in...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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Wiley
2019
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| _version_ | 1826288714180984832 |
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| author | Rådholm, K Zhou, Z Clemens, K Neal, B Woodward, M |
| author_facet | Rådholm, K Zhou, Z Clemens, K Neal, B Woodward, M |
| author_sort | Rådholm, K |
| collection | OXFORD |
| description | Sodium‐glucose co‐transporter‐2 (SGLT2) inhibitors prevent cardiovascular complications in type 2 diabetes. We aimed to study whether they have similar effects in women and men by summarizing the effects of SGLT2 inhibitors compared to placebo on vascular and safety outcomes stratified by sex. We included patients with type 2 diabetes enrolled in the EMPA‐REG OUTCOME, CANVAS Program, DECLARE TIMI‐58 and CREDENCE trials. There were no differences in the risk ratios between men and women, SGLT2 versus control (placebo), for vascular efficacy outcomes or death (all P for interaction ≥.12), with clear protection shown against major adverse cardiovascular events, heart failure, vascular death and total mortality. SGLT2 inhibitor treatment was also associated with similar relative risks in women and men for the safety outcomes of amputation, fracture, genital infection and urinary tract infection (all P for interaction ≥.17). SGLT2 inhibition provided similar protection against vascular risks and death, and similar risks of serious adverse events, for women and men. |
| first_indexed | 2024-03-07T02:17:52Z |
| format | Journal article |
| id | oxford-uuid:a2e3242b-9b9f-478c-8c88-10d6456a7add |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:17:52Z |
| publishDate | 2019 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:a2e3242b-9b9f-478c-8c88-10d6456a7add2022-03-27T02:23:03ZEffects of sodium‐glucose co‐transporter‐2 inhibitors in type 2 diabetes in women versus menJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a2e3242b-9b9f-478c-8c88-10d6456a7addEnglishSymplectic Elements at OxfordWiley2019Rådholm, KZhou, ZClemens, KNeal, BWoodward, MSodium‐glucose co‐transporter‐2 (SGLT2) inhibitors prevent cardiovascular complications in type 2 diabetes. We aimed to study whether they have similar effects in women and men by summarizing the effects of SGLT2 inhibitors compared to placebo on vascular and safety outcomes stratified by sex. We included patients with type 2 diabetes enrolled in the EMPA‐REG OUTCOME, CANVAS Program, DECLARE TIMI‐58 and CREDENCE trials. There were no differences in the risk ratios between men and women, SGLT2 versus control (placebo), for vascular efficacy outcomes or death (all P for interaction ≥.12), with clear protection shown against major adverse cardiovascular events, heart failure, vascular death and total mortality. SGLT2 inhibitor treatment was also associated with similar relative risks in women and men for the safety outcomes of amputation, fracture, genital infection and urinary tract infection (all P for interaction ≥.17). SGLT2 inhibition provided similar protection against vascular risks and death, and similar risks of serious adverse events, for women and men. |
| spellingShingle | Rådholm, K Zhou, Z Clemens, K Neal, B Woodward, M Effects of sodium‐glucose co‐transporter‐2 inhibitors in type 2 diabetes in women versus men |
| title | Effects of sodium‐glucose co‐transporter‐2 inhibitors in type 2 diabetes in women versus men |
| title_full | Effects of sodium‐glucose co‐transporter‐2 inhibitors in type 2 diabetes in women versus men |
| title_fullStr | Effects of sodium‐glucose co‐transporter‐2 inhibitors in type 2 diabetes in women versus men |
| title_full_unstemmed | Effects of sodium‐glucose co‐transporter‐2 inhibitors in type 2 diabetes in women versus men |
| title_short | Effects of sodium‐glucose co‐transporter‐2 inhibitors in type 2 diabetes in women versus men |
| title_sort | effects of sodium glucose co transporter 2 inhibitors in type 2 diabetes in women versus men |
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