Analysis of the human alpha globin upstream regulatory element (HS-40) in transgenic mice.
We have analysed the effect of a 1.4 kb segment of DNA containing the upstream alpha globin regulatory element (HS-40) on human alpha globin gene expression in fetal mice and lines of transgenic mice. High levels of tissue-specific, human alpha mRNA expression were seen in all transgenic animals and...
Prif Awduron: | Sharpe, J, Chan-Thomas, P, Lida, J, Ayyub, H, Wood, W, Higgs, D |
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Fformat: | Journal article |
Iaith: | English |
Cyhoeddwyd: |
1992
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Eitemau Tebyg
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Chromosome looping at the human alpha-globin locus is mediated via the major upstream regulatory element (HS -40).
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Deletion of the mouse alpha-globin regulatory element (HS -26) has an unexpectedly mild phenotype.
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Deletion of the mouse alpha globin regulatory element (HS-26) has an unexpectedly mild phenotype.
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The mouse alpha-globin locus regulatory element.
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Contrasting effects of alpha and beta globin regulatory elements on chromatin structure may be related to their different chromosomal environments.
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