Care practices and outcomes of extremely preterm neonates born at 22-24 weeks - a single centre experience
<p><strong>BACKGROUND:</strong> Wide variation in the care practices and survival rates of neonates born at peri-viable gestational ages of 22+0 – 24+6 weeks. This study elucidates the postnatal risk factors for morbidity/mortality, contrasts the care practices and short-term outco...
Main Authors: | , , , , , |
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Format: | Journal article |
Language: | English |
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IOS Press
2021
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author | Ramaswamy, VV Oommen, VI Gupta, A Weerapperuma, N Zivanovic, S Roehr, CC |
author_facet | Ramaswamy, VV Oommen, VI Gupta, A Weerapperuma, N Zivanovic, S Roehr, CC |
author_sort | Ramaswamy, VV |
collection | OXFORD |
description | <p><strong>BACKGROUND:</strong> Wide variation in the care practices and survival rates of neonates born at peri-viable gestational ages of 22+0 – 24+6 weeks. This study elucidates the postnatal risk factors for morbidity/mortality, contrasts the care practices and short-term outcomes of this vulnerable group of preterm neonates from a single center with others.</p>
<p><strong>METHODS:</strong> Retrospective study of neonates born at 22+0 –24+6 weeks in a level 3 neonatal intensive care unit in UK, over a period of 4 years (2016–2019). RESULTS:94 neonates given active care were studied. Survival until discharge was 51.1%(22–23 wks –44%, 24 wks –59.1%) and survival with no major brain injury (MBI) [grade III/IV IVH, cystic periventricular leukomalacia] was 38.3%(22–23 wks –32%, 24 wks –45.4%). Of those who survived until discharge, 75%had no MBI (22–23 wks –72.7%, 24 wks –76.9%). Neonates requiring significant respiratory support within first 72 hours as well as needing rescue high frequency ventilation had significantly high risk of mortality or MBI [aOR –7.17 (2.24–25.79), p = 0.00; 4.76 (1.43–20.00), p = 0.01].</p>
<p><strong>CONCLUSIONS:</strong> Survival rate differed from other centres. MBI was low amongst survivors. Severe respiratory disease in the initial days was associated with a higher risk of death or MBI.</p> |
first_indexed | 2024-03-07T02:18:16Z |
format | Journal article |
id | oxford-uuid:a30438fa-ffdc-47a9-aafb-de3039cd5e4e |
institution | University of Oxford |
language | English |
last_indexed | 2024-03-07T02:18:16Z |
publishDate | 2021 |
publisher | IOS Press |
record_format | dspace |
spelling | oxford-uuid:a30438fa-ffdc-47a9-aafb-de3039cd5e4e2022-03-27T02:23:56ZCare practices and outcomes of extremely preterm neonates born at 22-24 weeks - a single centre experienceJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a30438fa-ffdc-47a9-aafb-de3039cd5e4eEnglishSymplectic ElementsIOS Press2021Ramaswamy, VVOommen, VIGupta, AWeerapperuma, NZivanovic, SRoehr, CC<p><strong>BACKGROUND:</strong> Wide variation in the care practices and survival rates of neonates born at peri-viable gestational ages of 22+0 – 24+6 weeks. This study elucidates the postnatal risk factors for morbidity/mortality, contrasts the care practices and short-term outcomes of this vulnerable group of preterm neonates from a single center with others.</p> <p><strong>METHODS:</strong> Retrospective study of neonates born at 22+0 –24+6 weeks in a level 3 neonatal intensive care unit in UK, over a period of 4 years (2016–2019). RESULTS:94 neonates given active care were studied. Survival until discharge was 51.1%(22–23 wks –44%, 24 wks –59.1%) and survival with no major brain injury (MBI) [grade III/IV IVH, cystic periventricular leukomalacia] was 38.3%(22–23 wks –32%, 24 wks –45.4%). Of those who survived until discharge, 75%had no MBI (22–23 wks –72.7%, 24 wks –76.9%). Neonates requiring significant respiratory support within first 72 hours as well as needing rescue high frequency ventilation had significantly high risk of mortality or MBI [aOR –7.17 (2.24–25.79), p = 0.00; 4.76 (1.43–20.00), p = 0.01].</p> <p><strong>CONCLUSIONS:</strong> Survival rate differed from other centres. MBI was low amongst survivors. Severe respiratory disease in the initial days was associated with a higher risk of death or MBI.</p> |
spellingShingle | Ramaswamy, VV Oommen, VI Gupta, A Weerapperuma, N Zivanovic, S Roehr, CC Care practices and outcomes of extremely preterm neonates born at 22-24 weeks - a single centre experience |
title | Care practices and outcomes of extremely preterm neonates born at 22-24 weeks - a single centre experience |
title_full | Care practices and outcomes of extremely preterm neonates born at 22-24 weeks - a single centre experience |
title_fullStr | Care practices and outcomes of extremely preterm neonates born at 22-24 weeks - a single centre experience |
title_full_unstemmed | Care practices and outcomes of extremely preterm neonates born at 22-24 weeks - a single centre experience |
title_short | Care practices and outcomes of extremely preterm neonates born at 22-24 weeks - a single centre experience |
title_sort | care practices and outcomes of extremely preterm neonates born at 22 24 weeks a single centre experience |
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