THE DERMO-EPIDERMAL INTERFACE IN LICHEN-PLANUS END LUPUS-ERYTHEMATOSUS
The pathogenesis of lichen planus (LP) and cutaneous lupus erythematosus (LE) was investigated by immunohistochemical staining of skin biopsies from eight patients with these conditions compared with controls. Monoclonal antibodies were directed against antigens of the various components of the base...
| मुख्य लेखकों: | , , , , , |
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| स्वरूप: | Journal article |
| प्रकाशित: |
1994
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| _version_ | 1826288742996901888 |
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| author | Marren, P Deberker, D Wojnarowska, F Davies, M Leigh, I Burge, S |
| author_facet | Marren, P Deberker, D Wojnarowska, F Davies, M Leigh, I Burge, S |
| author_sort | Marren, P |
| collection | OXFORD |
| description | The pathogenesis of lichen planus (LP) and cutaneous lupus erythematosus (LE) was investigated by immunohistochemical staining of skin biopsies from eight patients with these conditions compared with controls. Monoclonal antibodies were directed against antigens of the various components of the basement membrane zone. We found a differential, site specific response by these components to the inflammatory process. The structural collagens in the basal lamina underwent a primarily reparative response demonstrated by thickening and reduplicatian, whilst an epidermal, hemidesmosome-associated antigen was consistently disrupted and fragmented. Despite diverse clinical features there were similarities between these two diseases suggesting some common pathogenic mechanisms. |
| first_indexed | 2024-03-07T02:18:18Z |
| format | Journal article |
| id | oxford-uuid:a30703c2-e622-49fb-a09c-5960cb4ba0f9 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T02:18:18Z |
| publishDate | 1994 |
| record_format | dspace |
| spelling | oxford-uuid:a30703c2-e622-49fb-a09c-5960cb4ba0f92022-03-27T02:24:03ZTHE DERMO-EPIDERMAL INTERFACE IN LICHEN-PLANUS END LUPUS-ERYTHEMATOSUSJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a30703c2-e622-49fb-a09c-5960cb4ba0f9Symplectic Elements at Oxford1994Marren, PDeberker, DWojnarowska, FDavies, MLeigh, IBurge, SThe pathogenesis of lichen planus (LP) and cutaneous lupus erythematosus (LE) was investigated by immunohistochemical staining of skin biopsies from eight patients with these conditions compared with controls. Monoclonal antibodies were directed against antigens of the various components of the basement membrane zone. We found a differential, site specific response by these components to the inflammatory process. The structural collagens in the basal lamina underwent a primarily reparative response demonstrated by thickening and reduplicatian, whilst an epidermal, hemidesmosome-associated antigen was consistently disrupted and fragmented. Despite diverse clinical features there were similarities between these two diseases suggesting some common pathogenic mechanisms. |
| spellingShingle | Marren, P Deberker, D Wojnarowska, F Davies, M Leigh, I Burge, S THE DERMO-EPIDERMAL INTERFACE IN LICHEN-PLANUS END LUPUS-ERYTHEMATOSUS |
| title | THE DERMO-EPIDERMAL INTERFACE IN LICHEN-PLANUS END LUPUS-ERYTHEMATOSUS |
| title_full | THE DERMO-EPIDERMAL INTERFACE IN LICHEN-PLANUS END LUPUS-ERYTHEMATOSUS |
| title_fullStr | THE DERMO-EPIDERMAL INTERFACE IN LICHEN-PLANUS END LUPUS-ERYTHEMATOSUS |
| title_full_unstemmed | THE DERMO-EPIDERMAL INTERFACE IN LICHEN-PLANUS END LUPUS-ERYTHEMATOSUS |
| title_short | THE DERMO-EPIDERMAL INTERFACE IN LICHEN-PLANUS END LUPUS-ERYTHEMATOSUS |
| title_sort | dermo epidermal interface in lichen planus end lupus erythematosus |
| work_keys_str_mv | AT marrenp thedermoepidermalinterfaceinlichenplanusendlupuserythematosus AT deberkerd thedermoepidermalinterfaceinlichenplanusendlupuserythematosus AT wojnarowskaf thedermoepidermalinterfaceinlichenplanusendlupuserythematosus AT daviesm thedermoepidermalinterfaceinlichenplanusendlupuserythematosus AT leighi thedermoepidermalinterfaceinlichenplanusendlupuserythematosus AT burges thedermoepidermalinterfaceinlichenplanusendlupuserythematosus AT marrenp dermoepidermalinterfaceinlichenplanusendlupuserythematosus AT deberkerd dermoepidermalinterfaceinlichenplanusendlupuserythematosus AT wojnarowskaf dermoepidermalinterfaceinlichenplanusendlupuserythematosus AT daviesm dermoepidermalinterfaceinlichenplanusendlupuserythematosus AT leighi dermoepidermalinterfaceinlichenplanusendlupuserythematosus AT burges dermoepidermalinterfaceinlichenplanusendlupuserythematosus |