Long-term wireless streaming of neural recordings for circuit discovery and adaptive stimulation in individuals with Parkinson’s disease
Neural recordings using invasive devices in humans can elucidate the circuits underlying brain disorders, but have so far been limited to short recordings from externalized brain leads in a hospital setting or from implanted sensing devices that provide only intermittent, brief streaming of time ser...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature
2021
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| _version_ | 1826288748117098496 |
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| author | Gilron, R Little, S Perrone, R Wilt, R de Hemptinne, C Yaroshinsky, MS Racine, CA Wang, SS Ostrem, JL Larson, PS Wang, DD Galifianakis, NB Bledsoe, IO San Luciano, M Dawes, HE Worrell, GA Kremen, V Borton, DA Denison, T Starr, PA |
| author_facet | Gilron, R Little, S Perrone, R Wilt, R de Hemptinne, C Yaroshinsky, MS Racine, CA Wang, SS Ostrem, JL Larson, PS Wang, DD Galifianakis, NB Bledsoe, IO San Luciano, M Dawes, HE Worrell, GA Kremen, V Borton, DA Denison, T Starr, PA |
| author_sort | Gilron, R |
| collection | OXFORD |
| description | Neural recordings using invasive devices in humans can elucidate the circuits underlying brain disorders, but have so far been limited to short recordings from externalized brain leads in a hospital setting or from implanted sensing devices that provide only intermittent, brief streaming of time series data. Here, we report the use of an implantable two-way neural interface for wireless, multichannel streaming of field potentials in five individuals with Parkinson’s disease (PD) for up to 15 months after implantation. Bilateral four-channel motor cortex and basal ganglia field potentials streamed at home for over 2,600 h were paired with behavioral data from wearable monitors for the neural decoding of states of inadequate or excessive movement. We validated individual-specific neurophysiological biomarkers during normal daily activities and used those patterns for adaptive deep brain stimulation (DBS). This technological approach may be widely applicable to brain disorders treatable by invasive neuromodulation. |
| first_indexed | 2024-03-07T02:18:23Z |
| format | Journal article |
| id | oxford-uuid:a30d9501-c1b1-485c-a67e-396d6023094e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:18:23Z |
| publishDate | 2021 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:a30d9501-c1b1-485c-a67e-396d6023094e2022-03-27T02:24:24ZLong-term wireless streaming of neural recordings for circuit discovery and adaptive stimulation in individuals with Parkinson’s diseaseJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a30d9501-c1b1-485c-a67e-396d6023094eEnglishSymplectic ElementsSpringer Nature2021Gilron, RLittle, SPerrone, RWilt, Rde Hemptinne, CYaroshinsky, MSRacine, CAWang, SSOstrem, JLLarson, PSWang, DDGalifianakis, NBBledsoe, IOSan Luciano, MDawes, HEWorrell, GAKremen, VBorton, DADenison, TStarr, PANeural recordings using invasive devices in humans can elucidate the circuits underlying brain disorders, but have so far been limited to short recordings from externalized brain leads in a hospital setting or from implanted sensing devices that provide only intermittent, brief streaming of time series data. Here, we report the use of an implantable two-way neural interface for wireless, multichannel streaming of field potentials in five individuals with Parkinson’s disease (PD) for up to 15 months after implantation. Bilateral four-channel motor cortex and basal ganglia field potentials streamed at home for over 2,600 h were paired with behavioral data from wearable monitors for the neural decoding of states of inadequate or excessive movement. We validated individual-specific neurophysiological biomarkers during normal daily activities and used those patterns for adaptive deep brain stimulation (DBS). This technological approach may be widely applicable to brain disorders treatable by invasive neuromodulation. |
| spellingShingle | Gilron, R Little, S Perrone, R Wilt, R de Hemptinne, C Yaroshinsky, MS Racine, CA Wang, SS Ostrem, JL Larson, PS Wang, DD Galifianakis, NB Bledsoe, IO San Luciano, M Dawes, HE Worrell, GA Kremen, V Borton, DA Denison, T Starr, PA Long-term wireless streaming of neural recordings for circuit discovery and adaptive stimulation in individuals with Parkinson’s disease |
| title | Long-term wireless streaming of neural recordings for circuit discovery and adaptive stimulation in individuals with Parkinson’s disease |
| title_full | Long-term wireless streaming of neural recordings for circuit discovery and adaptive stimulation in individuals with Parkinson’s disease |
| title_fullStr | Long-term wireless streaming of neural recordings for circuit discovery and adaptive stimulation in individuals with Parkinson’s disease |
| title_full_unstemmed | Long-term wireless streaming of neural recordings for circuit discovery and adaptive stimulation in individuals with Parkinson’s disease |
| title_short | Long-term wireless streaming of neural recordings for circuit discovery and adaptive stimulation in individuals with Parkinson’s disease |
| title_sort | long term wireless streaming of neural recordings for circuit discovery and adaptive stimulation in individuals with parkinson s disease |
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