Click JAHAs: Conformationally restricted ferrocene-based histone deacetylase inhibitors
A small library of ferrocene-based 1,2,3-triazole-containing hydroxamic acids has been synthesised employing click chemistry: 7-(4-ferrocenyl-1H-1,2,3- triazol-1-yl)-N-hydroxyheptanamide, 4b, containing the 1,2,3-triazole moiety adjacent to the ferrocene group, displayed excellent HDAC inhibition an...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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| _version_ | 1797086198489939968 |
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| author | Spencer, J Amin, J Boddiboyena, R Packham, G Cavell, B Syed Alwi, S Paranal, R Heightman, T Wang, M Marsden, B Coxhead, P Guille, M Tizzard, G Coles, S Bradner, J |
| author_facet | Spencer, J Amin, J Boddiboyena, R Packham, G Cavell, B Syed Alwi, S Paranal, R Heightman, T Wang, M Marsden, B Coxhead, P Guille, M Tizzard, G Coles, S Bradner, J |
| author_sort | Spencer, J |
| collection | OXFORD |
| description | A small library of ferrocene-based 1,2,3-triazole-containing hydroxamic acids has been synthesised employing click chemistry: 7-(4-ferrocenyl-1H-1,2,3- triazol-1-yl)-N-hydroxyheptanamide, 4b, containing the 1,2,3-triazole moiety adjacent to the ferrocene group, displayed excellent HDAC inhibition and activity in cells, inhibiting the deacetylation of tubulin as well as inducing cell cycle arrest. This journal is © The Royal Society of Chemistry. |
| first_indexed | 2024-03-07T02:18:40Z |
| format | Journal article |
| id | oxford-uuid:a327b6d3-2d0e-43bd-ae65-b49efb288f42 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:18:40Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:a327b6d3-2d0e-43bd-ae65-b49efb288f422022-03-27T02:24:53ZClick JAHAs: Conformationally restricted ferrocene-based histone deacetylase inhibitorsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a327b6d3-2d0e-43bd-ae65-b49efb288f42EnglishSymplectic Elements at Oxford2012Spencer, JAmin, JBoddiboyena, RPackham, GCavell, BSyed Alwi, SParanal, RHeightman, TWang, MMarsden, BCoxhead, PGuille, MTizzard, GColes, SBradner, JA small library of ferrocene-based 1,2,3-triazole-containing hydroxamic acids has been synthesised employing click chemistry: 7-(4-ferrocenyl-1H-1,2,3- triazol-1-yl)-N-hydroxyheptanamide, 4b, containing the 1,2,3-triazole moiety adjacent to the ferrocene group, displayed excellent HDAC inhibition and activity in cells, inhibiting the deacetylation of tubulin as well as inducing cell cycle arrest. This journal is © The Royal Society of Chemistry. |
| spellingShingle | Spencer, J Amin, J Boddiboyena, R Packham, G Cavell, B Syed Alwi, S Paranal, R Heightman, T Wang, M Marsden, B Coxhead, P Guille, M Tizzard, G Coles, S Bradner, J Click JAHAs: Conformationally restricted ferrocene-based histone deacetylase inhibitors |
| title | Click JAHAs: Conformationally restricted ferrocene-based histone deacetylase inhibitors |
| title_full | Click JAHAs: Conformationally restricted ferrocene-based histone deacetylase inhibitors |
| title_fullStr | Click JAHAs: Conformationally restricted ferrocene-based histone deacetylase inhibitors |
| title_full_unstemmed | Click JAHAs: Conformationally restricted ferrocene-based histone deacetylase inhibitors |
| title_short | Click JAHAs: Conformationally restricted ferrocene-based histone deacetylase inhibitors |
| title_sort | click jahas conformationally restricted ferrocene based histone deacetylase inhibitors |
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