Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

The endogenous metabolite itaconate has recently emerged as a regulator of macrophage function, but its precise mechanism of action remains poorly understood1,2,3. Here we show that itaconate is required for the activation of the anti-inflammatory transcription factor Nrf2 (also known as NFE2L2) by...

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Bibliographic Details
Main Authors: Mills, EL, Ryan, DG, Prag, HA, Dikovskaya, D, Menon, D, Zaslona, Z, Jedrychowski, MP, Costa, ASH, Higgins, M, Hams, E, Szpyt, J, Runtsch, MC, King, MS, McGouran, JF, Fischer, R, Kessler, BM, McGettrick, AF, Hughes, MM, Carroll, RG, Booty, LM, Knatko, EV, Meakin, PJ, Ashford, MLJ, Modis, LK, Brunori, G, Sévin, DC, Fallon, PG, Caldwell, ST, Kunji, ERS, Chouchani, ET, Frezza, C, Dinkova-Kostova, AT, Hartley, RC, Murphy, MP, O'Neill, LA
Format: Journal article
Language:English
Published: Springer Nature 2018

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