Emergence of community-associated methicillin-resistant Staphylococcus aureus carriage in children in Cambodia.

We previously described the first reported isolation of methicillin-resistant Staphylococcus aureus (MRSA) (a case series of pediatric community-associated MRSA infections) in Cambodia. We define the rate of pediatric MRSA carriage in the same population and characterize the associated bacterial gen...

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Những tác giả chính: Nickerson, E, Wuthiekanun, V, Kumar, V, Amornchai, P, Wongdeethai, N, Chheng, K, Chantratita, N, Putchhat, H, Thaipadungpanit, J, Day, N, Peacock, S
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 2011
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author Nickerson, E
Wuthiekanun, V
Kumar, V
Amornchai, P
Wongdeethai, N
Chheng, K
Chantratita, N
Putchhat, H
Thaipadungpanit, J
Day, N
Peacock, S
author_facet Nickerson, E
Wuthiekanun, V
Kumar, V
Amornchai, P
Wongdeethai, N
Chheng, K
Chantratita, N
Putchhat, H
Thaipadungpanit, J
Day, N
Peacock, S
author_sort Nickerson, E
collection OXFORD
description We previously described the first reported isolation of methicillin-resistant Staphylococcus aureus (MRSA) (a case series of pediatric community-associated MRSA infections) in Cambodia. We define the rate of pediatric MRSA carriage in the same population and characterize the associated bacterial genotypes by using pulsed-field gel electrophoresis and multilocus sequence typing. A prospective cohort study of MRSA carriage conducted over one month at the Angkor Hospital for Children, Siem Reap, Cambodia, identified MRSA carriage in 87 (3.5%) of 2,485 children who came to the outpatient department, and 6 (4.1%) of 145 inpatients, including at least two with cases of nosocomial acquisition. Genotyping of all 93 MRSA isolates resolved 5 genotypes. Most (91%) isolates were assigned to sequence type 834. Only 28 (32%) of 87 MRSA carriers identified in the outpatient department had no history of recent healthcare contact. The study findings have important implications for healthcare in a setting where diagnostic microbiology and access to antimicrobial drugs with efficacy against MRSA are limited.
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spelling oxford-uuid:a338e32e-dd6c-4f04-8529-3b56b3d092c82022-03-27T02:25:23ZEmergence of community-associated methicillin-resistant Staphylococcus aureus carriage in children in Cambodia.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a338e32e-dd6c-4f04-8529-3b56b3d092c8EnglishSymplectic Elements at Oxford2011Nickerson, EWuthiekanun, VKumar, VAmornchai, PWongdeethai, NChheng, KChantratita, NPutchhat, HThaipadungpanit, JDay, NPeacock, SWe previously described the first reported isolation of methicillin-resistant Staphylococcus aureus (MRSA) (a case series of pediatric community-associated MRSA infections) in Cambodia. We define the rate of pediatric MRSA carriage in the same population and characterize the associated bacterial genotypes by using pulsed-field gel electrophoresis and multilocus sequence typing. A prospective cohort study of MRSA carriage conducted over one month at the Angkor Hospital for Children, Siem Reap, Cambodia, identified MRSA carriage in 87 (3.5%) of 2,485 children who came to the outpatient department, and 6 (4.1%) of 145 inpatients, including at least two with cases of nosocomial acquisition. Genotyping of all 93 MRSA isolates resolved 5 genotypes. Most (91%) isolates were assigned to sequence type 834. Only 28 (32%) of 87 MRSA carriers identified in the outpatient department had no history of recent healthcare contact. The study findings have important implications for healthcare in a setting where diagnostic microbiology and access to antimicrobial drugs with efficacy against MRSA are limited.
spellingShingle Nickerson, E
Wuthiekanun, V
Kumar, V
Amornchai, P
Wongdeethai, N
Chheng, K
Chantratita, N
Putchhat, H
Thaipadungpanit, J
Day, N
Peacock, S
Emergence of community-associated methicillin-resistant Staphylococcus aureus carriage in children in Cambodia.
title Emergence of community-associated methicillin-resistant Staphylococcus aureus carriage in children in Cambodia.
title_full Emergence of community-associated methicillin-resistant Staphylococcus aureus carriage in children in Cambodia.
title_fullStr Emergence of community-associated methicillin-resistant Staphylococcus aureus carriage in children in Cambodia.
title_full_unstemmed Emergence of community-associated methicillin-resistant Staphylococcus aureus carriage in children in Cambodia.
title_short Emergence of community-associated methicillin-resistant Staphylococcus aureus carriage in children in Cambodia.
title_sort emergence of community associated methicillin resistant staphylococcus aureus carriage in children in cambodia
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