Magnetic nanoparticles supporting bio-responsive T1/T2 magnetic resonance imaging
The use of nanoparticulate systems as contrast agents for magnetic resonance imaging (MRI) is well-established and known to facilitate an enhanced image sensitivity within scans of a particular pathological region of interest. Such a capability can enable both a non-invasive diagnosis and the monito...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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MDPI
2019
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| _version_ | 1797086234658471936 |
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| author | Ellis, CM Pellico, J Davis, JJ |
| author_facet | Ellis, CM Pellico, J Davis, JJ |
| author_sort | Ellis, CM |
| collection | OXFORD |
| description | The use of nanoparticulate systems as contrast agents for magnetic resonance imaging (MRI) is well-established and known to facilitate an enhanced image sensitivity within scans of a particular pathological region of interest. Such a capability can enable both a non-invasive diagnosis and the monitoring of disease progression/response to treatment. In this review, magnetic nanoparticles that exhibit a bio-responsive MR relaxivity are discussed, with pH-, enzyme-, biomolecular-, and protein-responsive systems considered. The ability of a contrast agent to respond to a biological stimulus provides not only enriched diagnostic capabilities over corresponding non-responsive analogues, but also an improved longitudinal monitoring of specific physiological conditions. |
| first_indexed | 2024-03-07T02:19:14Z |
| format | Journal article |
| id | oxford-uuid:a3524933-eefe-44f1-a4de-f21a59bea63b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:19:14Z |
| publishDate | 2019 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oxford-uuid:a3524933-eefe-44f1-a4de-f21a59bea63b2022-03-27T02:26:14ZMagnetic nanoparticles supporting bio-responsive T1/T2 magnetic resonance imagingJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a3524933-eefe-44f1-a4de-f21a59bea63bEnglishSymplectic ElementsMDPI2019Ellis, CMPellico, JDavis, JJThe use of nanoparticulate systems as contrast agents for magnetic resonance imaging (MRI) is well-established and known to facilitate an enhanced image sensitivity within scans of a particular pathological region of interest. Such a capability can enable both a non-invasive diagnosis and the monitoring of disease progression/response to treatment. In this review, magnetic nanoparticles that exhibit a bio-responsive MR relaxivity are discussed, with pH-, enzyme-, biomolecular-, and protein-responsive systems considered. The ability of a contrast agent to respond to a biological stimulus provides not only enriched diagnostic capabilities over corresponding non-responsive analogues, but also an improved longitudinal monitoring of specific physiological conditions. |
| spellingShingle | Ellis, CM Pellico, J Davis, JJ Magnetic nanoparticles supporting bio-responsive T1/T2 magnetic resonance imaging |
| title | Magnetic nanoparticles supporting bio-responsive T1/T2 magnetic resonance imaging |
| title_full | Magnetic nanoparticles supporting bio-responsive T1/T2 magnetic resonance imaging |
| title_fullStr | Magnetic nanoparticles supporting bio-responsive T1/T2 magnetic resonance imaging |
| title_full_unstemmed | Magnetic nanoparticles supporting bio-responsive T1/T2 magnetic resonance imaging |
| title_short | Magnetic nanoparticles supporting bio-responsive T1/T2 magnetic resonance imaging |
| title_sort | magnetic nanoparticles supporting bio responsive t1 t2 magnetic resonance imaging |
| work_keys_str_mv | AT elliscm magneticnanoparticlessupportingbioresponsivet1t2magneticresonanceimaging AT pellicoj magneticnanoparticlessupportingbioresponsivet1t2magneticresonanceimaging AT davisjj magneticnanoparticlessupportingbioresponsivet1t2magneticresonanceimaging |