Interactions between residues in staphylococcal alpha-hemolysin revealed by reversion mutagenesis.

Interactions between residues in staphylococcal alpha-hemolysin revealed by reversion mutagenesis.

alpha-Hemolysin (alpha HL), a pore-forming polypeptide of 293 amino acids, is secreted by Staphylococcus aureus as a water-soluble monomer. Residues that play key roles in the formation of functional heptameric pores on rabbit red blood cells (rRBC) have been identified previously by site-directed m...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Panchal, R, Bayley, H
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	1995

Eitemau Tebyg

Assembly of the oligomeric membrane pore formed by Staphylococcal alpha-hemolysin examined by truncation mutagenesis.
gan: Walker, B, et al.
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Key residues for membrane binding, oligomerization, and pore forming activity of staphylococcal alpha-hemolysin identified by cysteine scanning mutagenesis and targeted chemical modification.
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Surface labeling of key residues during assembly of the transmembrane pore formed by staphylococcal alpha-hemolysin.
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Cyhoeddwyd: (1994)

The internal cavity of the staphylococcal alpha-hemolysin pore accommodates approximately 175 exogenous amino acid residues.
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Cyhoeddwyd: (2005)

Structure of staphylococcal alpha-hemolysin, a heptameric transmembrane pore.
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Cyhoeddwyd: (1996)

Spontaneous oligomerization of a staphylococcal alpha-hemolysin conformationally constrained by removal of residues that form the transmembrane beta-barrel.
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Redirecting pore assembly of staphylococcal α-hemolysin by protein engineering
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Cyhoeddwyd: (2019)

Subunit stoichiometry of staphylococcal alpha-hemolysin in crystals and on membranes: a heptameric transmembrane pore.
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Cyhoeddwyd: (1994)

Translocating kilobase RNA through the Staphylococcal α-hemolysin nanopore.
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Cyhoeddwyd: (2013)

Imaging the assembly of the Staphylococcal pore-forming toxin alpha-Hemolysin
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Redirecting Pore Assembly of Staphylococcal α‑Hemolysin by Protein Engineering
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Subunit dimers of alpha-hemolysin expand the engineering toolbox for protein nanopores.
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Nucleobase recognition in ssDNA at the central constriction of the alpha-hemolysin pore.
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Urea facilitates the translocation of single-stranded DNA and RNA through the alpha-hemolysin nanopore.
gan: Japrung, D, et al.
Cyhoeddwyd: (2010)

Molecular modeling reveals the novel inhibition mechanism and binding mode of three natural compounds to staphylococcal α-hemolysin.
gan: Jiazhang Qiu, et al.
Cyhoeddwyd: (2013-01-01)

Two residues in Staphylococcus aureus α-hemolysin related to hemolysis and self-assembly
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Cyhoeddwyd: (2018-08-01)

Enhanced translocation of single DNA molecules through alpha-hemolysin nanopores by manipulation of internal charge.
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Cyhoeddwyd: (2008)

Membrane bound monomer of Staphylococcal alpha-hemolysin induces caspase activation and apoptotic cell death despite initiation of membrane repair pathway.
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Probabilistic Study on Subunit Mismatch Arrangement in Staphylococcal γ-hemolysin Heteroheptameric Transmembrane Pore
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Visualization of multivalent binding events using α-hemolysin
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Molecular architecture of a toxin pore: a 15-residue sequence lines the transmembrane channel of staphylococcal alpha-toxin.
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Cyhoeddwyd: (1996)

RNase A does not translocate the alpha-hemolysin pore.
gan: Besnik Krasniqi, et al.
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Delta Hemolysin and Phenol-soluble Modulins, but not Alpha Hemolysin or Panton-Valentine Leukocidin, Induce Mast Cell Activation
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Properties of Bacillus cereus hemolysin II: a heptameric transmembrane pore.
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Transmembrane beta-barrel of staphylococcal alpha-toxin forms in sensitive but not in resistant cells.
gan: Valeva, A, et al.
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Single-molecule chemistry studies with engineered alpha-hemolysin pores
gan: Hammerstein, A
Cyhoeddwyd: (2011)

Model-based prediction of the alpha-hemolysin structure in the hexameric state.
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Cyhoeddwyd: (2008)

Membrane-Damaging Activity Against Various Phospholipid Liposomes by γ-hemolysin, Staphylococcal Two-Component Pore-Forming Cytolysin
gan: Noriko TOMITA, et al.
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Enhanced secretory production of hemolysin-mediated cyclodextrin-glucanotransferase in Escherichia coli by random mutagenesis of the ABC transporter system.
gan: Kheng, Oon Low, et al.
Cyhoeddwyd: (2010)

Common origin of plasmid encoded alpha-hemolysin genes in <it>Escherichia coli</it>
gan: Beutin Lothar, et al.
Cyhoeddwyd: (2010-07-01)

Biomedical diagnosis perspective of epigenetic detections using alpha-hemolysin nanopore
gan: Yong Wang, et al.
Cyhoeddwyd: (2015-11-01)

ELISA for Alpha-hemolysin (Hla) in Methicilin-resistant Staphylococcus aureus (MRSA)
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Cyhoeddwyd: (2014-05-01)

Above and beyond C5a Receptor Targeting by Staphylococcal Leucotoxins: Retrograde Transport of Panton–Valentine Leucocidin and γ-Hemolysin
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Fluorinated amphiphiles control the insertion of α-hemolysin pores into lipid bilayers.
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Cyhoeddwyd: (2011)

Functional expression of the alpha-hemolysin of Staphylococcus aureus in intact Escherichia coli and in cell lysates. Deletion of five C-terminal amino acids selectively impairs hemolytic activity.
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Cyhoeddwyd: (1992)

Suppressing Alpha-Hemolysin as Potential Target to Screen of Flavonoids to Combat Bacterial Coinfection
gan: Shangwen He, et al.
Cyhoeddwyd: (2021-12-01)

Chalcone Attenuates Staphylococcus aureus Virulence by Targeting Sortase A and Alpha-Hemolysin
gan: Bing Zhang, et al.
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Designing a light-activated recombinant alpha hemolysin for colorectal cancer targeting
gan: Siamak Alizadeh, et al.
Cyhoeddwyd: (2020-07-01)

Site-directed mutagenesis to determine the role of surface exposed lysine on the stability of staphylococcal lipase
gan: Ahmad, Nurul Nadirah
Cyhoeddwyd: (2020)

Microcalorimetric Investigations of Reversible Staphylococcal Enterotoxin Unfolding
gan: Susan C. Berry, et al.
Cyhoeddwyd: (2022-08-01)