Assessing the prognostic value of preoperative carcinoembryonic antigen-specific T-cell responses in colorectal cancer
Current dogma suggests that tumor-reactive IFN-γ–producing (T<sub>H</sub>1-type) T-cells are beneficial to patient outcome; however, the clinical consequence of these responses with respect to long-term prognosis in colorectal cancer (CRC) is not understood. Here, we compared the utility...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Oxford University Press
2015
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| _version_ | 1797086245329829888 |
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| author | Scurr, M Brown, C Bento, D Betts, G Rees, B Hills, R Gallimore, A Godkin, A |
| author_facet | Scurr, M Brown, C Bento, D Betts, G Rees, B Hills, R Gallimore, A Godkin, A |
| author_sort | Scurr, M |
| collection | OXFORD |
| description | Current dogma suggests that tumor-reactive IFN-γ–producing (T<sub>H</sub>1-type) T-cells are beneficial to patient outcome; however, the clinical consequence of these responses with respect to long-term prognosis in colorectal cancer (CRC) is not understood. Here, we compared the utility of preoperative, peripheral blood–derived IFN-γ<sup>+</sup> T-cell responses specific to carcinoembryonic antigen (CEA), 5T4, or control antigens (n = 64) with tumor staging and clinical details (n = 87) in predicting five-year outcome of CRC patients who underwent resection with curative intent. Although disease recurrence was more likely in patients with stage III tumors, the presence of preoperative, CEA-specific IFN-γ–producing T-cells identified patients at a statistically significantly greater risk of tumor recurrence following surgical resection, irrespective of tumor stage (odds ratio = 5.00, 95% confidence interval = 1.96 to 12.77, two-sided <em>P</em> <.001). Responses to other antigens, including 5T4, did not reflect outcome. Whilst these results initially appear surprising, they could improve prognostication and help redirect adjuvant treatments. |
| first_indexed | 2024-03-07T02:19:22Z |
| format | Journal article |
| id | oxford-uuid:a3608cd9-a47d-4a2a-b713-7c051e391c48 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:19:22Z |
| publishDate | 2015 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:a3608cd9-a47d-4a2a-b713-7c051e391c482022-03-27T02:26:32ZAssessing the prognostic value of preoperative carcinoembryonic antigen-specific T-cell responses in colorectal cancerJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a3608cd9-a47d-4a2a-b713-7c051e391c48EnglishORA DepositOxford University Press2015Scurr, MBrown, CBento, DBetts, GRees, BHills, RGallimore, AGodkin, ACurrent dogma suggests that tumor-reactive IFN-γ–producing (T<sub>H</sub>1-type) T-cells are beneficial to patient outcome; however, the clinical consequence of these responses with respect to long-term prognosis in colorectal cancer (CRC) is not understood. Here, we compared the utility of preoperative, peripheral blood–derived IFN-γ<sup>+</sup> T-cell responses specific to carcinoembryonic antigen (CEA), 5T4, or control antigens (n = 64) with tumor staging and clinical details (n = 87) in predicting five-year outcome of CRC patients who underwent resection with curative intent. Although disease recurrence was more likely in patients with stage III tumors, the presence of preoperative, CEA-specific IFN-γ–producing T-cells identified patients at a statistically significantly greater risk of tumor recurrence following surgical resection, irrespective of tumor stage (odds ratio = 5.00, 95% confidence interval = 1.96 to 12.77, two-sided <em>P</em> <.001). Responses to other antigens, including 5T4, did not reflect outcome. Whilst these results initially appear surprising, they could improve prognostication and help redirect adjuvant treatments. |
| spellingShingle | Scurr, M Brown, C Bento, D Betts, G Rees, B Hills, R Gallimore, A Godkin, A Assessing the prognostic value of preoperative carcinoembryonic antigen-specific T-cell responses in colorectal cancer |
| title | Assessing the prognostic value of preoperative carcinoembryonic antigen-specific T-cell responses in colorectal cancer |
| title_full | Assessing the prognostic value of preoperative carcinoembryonic antigen-specific T-cell responses in colorectal cancer |
| title_fullStr | Assessing the prognostic value of preoperative carcinoembryonic antigen-specific T-cell responses in colorectal cancer |
| title_full_unstemmed | Assessing the prognostic value of preoperative carcinoembryonic antigen-specific T-cell responses in colorectal cancer |
| title_short | Assessing the prognostic value of preoperative carcinoembryonic antigen-specific T-cell responses in colorectal cancer |
| title_sort | assessing the prognostic value of preoperative carcinoembryonic antigen specific t cell responses in colorectal cancer |
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