Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist.

Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist.

Oestrogens exert their physiological effects through two receptor subtypes. Here we report the three-dimensional structure of the oestrogen receptor beta isoform (ERbeta) ligand-binding domain (LBD) in the presence of the phyto-oestrogen genistein and the antagonist raloxifene. The overall structure...

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Bibliographic Details
Main Authors: Pike, A, Brzozowski, A, Hubbard, R, Bonn, T, Thorsell, A, Engström, O, Ljunggren, J, Gustafsson, J, Carlquist, M
Format: Journal article
Language:English
Published: 1999

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