Bone stromal cells in pagetic bone and Paget's sarcoma express RANKL and support human osteoclast formation.

Bone stromal cells in pagetic bone and Paget's sarcoma express RANKL and support human osteoclast formation.

Paget's disease is a focal disorder of bone remodelling, in which there is an increase in osteoclast formation. A rare complication of Paget's disease is the development of a sarcoma, most commonly an osteosarcoma. Osteoclast formation occurs in the presence of macrophage-colony stimulatin...

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Autors principals:	Sun, S, Lau, Y, Itonaga, I, Sabokbar, A, Athanasou, N
Format:	Journal article
Idioma:	English
Publicat:	2006

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