In situ functional dissection of RNA cis-regulatory elements by multiplex CRISPR-Cas9 genome engineering

In situ functional dissection of RNA cis-regulatory elements by multiplex CRISPR-Cas9 genome engineering

RNA regulatory elements (RREs) are an important yet relatively under-explored facet of gene regulation. Deciphering the prevalence and functional impact of this post-transcriptional control layer requires technologies for disrupting RREs without perturbing cellular homeostasis. Here we describe geno...

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Bibliographic Details
Main Authors: Wu, Q, Ferry, Q, Baeumler, T, Michaels, Y, Vitsios, D, Habib, O, Arnold, R, Jiang, X, Maio, S, Steinkraus, B, Tapia, M, Piazza, P, Xu, N, Holländer, G, Milne, T, Kim, J, Enright, A, Bassett, A, Fulga, T
Format: Journal article
Published: Springer Nature 2017

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