Crystal and solution structures of the oligonucleotide d(ATGCGCAT)2: a combined X-ray and NMR study.
A combined crystal-structure determination and NMR analysis of the octanucleotide d(ATGCGCAT)2 is reported. The X-ray analysis shows that the structure is A-form duplex in crystal state. The NMR study shows that in solution this sequence is B-type. The conformational results from each technique are...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1990
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| _version_ | 1826288858092797952 |
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| author | Clark, G Brown, D Sanderson, MR Chwalinski, T Neidle, S Veal, J Jones, R Wilson, W Zon, G Garman, E |
| author_facet | Clark, G Brown, D Sanderson, MR Chwalinski, T Neidle, S Veal, J Jones, R Wilson, W Zon, G Garman, E |
| author_sort | Clark, G |
| collection | OXFORD |
| description | A combined crystal-structure determination and NMR analysis of the octanucleotide d(ATGCGCAT)2 is reported. The X-ray analysis shows that the structure is A-form duplex in crystal state. The NMR study shows that in solution this sequence is B-type. The conformational results from each technique are presented in detail. The implications of these findings in terms of conformational flexibility and ligand binding are discussed. |
| first_indexed | 2024-03-07T02:20:04Z |
| format | Journal article |
| id | oxford-uuid:a398a0e3-be2b-4b85-ae56-946bdea24858 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:20:04Z |
| publishDate | 1990 |
| record_format | dspace |
| spelling | oxford-uuid:a398a0e3-be2b-4b85-ae56-946bdea248582022-03-27T02:28:15ZCrystal and solution structures of the oligonucleotide d(ATGCGCAT)2: a combined X-ray and NMR study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a398a0e3-be2b-4b85-ae56-946bdea24858EnglishSymplectic Elements at Oxford1990Clark, GBrown, DSanderson, MRChwalinski, TNeidle, SVeal, JJones, RWilson, WZon, GGarman, EA combined crystal-structure determination and NMR analysis of the octanucleotide d(ATGCGCAT)2 is reported. The X-ray analysis shows that the structure is A-form duplex in crystal state. The NMR study shows that in solution this sequence is B-type. The conformational results from each technique are presented in detail. The implications of these findings in terms of conformational flexibility and ligand binding are discussed. |
| spellingShingle | Clark, G Brown, D Sanderson, MR Chwalinski, T Neidle, S Veal, J Jones, R Wilson, W Zon, G Garman, E Crystal and solution structures of the oligonucleotide d(ATGCGCAT)2: a combined X-ray and NMR study. |
| title | Crystal and solution structures of the oligonucleotide d(ATGCGCAT)2: a combined X-ray and NMR study. |
| title_full | Crystal and solution structures of the oligonucleotide d(ATGCGCAT)2: a combined X-ray and NMR study. |
| title_fullStr | Crystal and solution structures of the oligonucleotide d(ATGCGCAT)2: a combined X-ray and NMR study. |
| title_full_unstemmed | Crystal and solution structures of the oligonucleotide d(ATGCGCAT)2: a combined X-ray and NMR study. |
| title_short | Crystal and solution structures of the oligonucleotide d(ATGCGCAT)2: a combined X-ray and NMR study. |
| title_sort | crystal and solution structures of the oligonucleotide d atgcgcat 2 a combined x ray and nmr study |
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