Myocardial native T1 and extracellular volume with healthy ageing and gender
<h4>Aims</h4> <p>To determine how native myocardial T1 and extracellular volume (ECV) change with age, both to understand aging and to inform on normal reference ranges.</p> <h4>Methods and results</h4> <p>Ninety-four healthy volunteers with no a history or...
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Oxford University Press
2018
|
| _version_ | 1797086300357001216 |
|---|---|
| author | Rosmini, S Bulluck, H Captur, G Treibel, T Abdel-Gadir, A Bhuva, A Culotta, V Merghani, A Fontana, M Maestrini, V Herrey, A Chow, K Thompson, R Piechnik, S Kellman, P Manisty, C Moon, J |
| author_facet | Rosmini, S Bulluck, H Captur, G Treibel, T Abdel-Gadir, A Bhuva, A Culotta, V Merghani, A Fontana, M Maestrini, V Herrey, A Chow, K Thompson, R Piechnik, S Kellman, P Manisty, C Moon, J |
| author_sort | Rosmini, S |
| collection | OXFORD |
| description | <h4>Aims</h4> <p>To determine how native myocardial T1 and extracellular volume (ECV) change with age, both to understand aging and to inform on normal reference ranges.</p> <h4>Methods and results</h4> <p>Ninety-four healthy volunteers with no a history or symptoms of cardiovascular disease or diabetes underwent cardiovascular magnetic resonance at 1.5 T. Mid-ventricular short axis native and post-contrast T1 maps by Shortened MOdified Look-Locker Inversion-recovery (ShMOLLI), MOdified Look-Locker Inversion Recovery (MOLLI) [pre-contrast: 5s(3s)3s, post-contrast: 4s(1s)3s(1s)2s] and saturation recovery single-shot acquisition (SASHA) were acquired and ECV by these three techniques were derived for the mid anteroseptum. Mean age was 50 ± 14 years (range 20-76), male 52%, with no age difference between genders (males 51 ± 14 years; females 49 ± 15 years, P = 0.55). Quoting respectively ShMOLLI, MOLLI, SASHA throughout, mean myocardial T1 was 957 ± 30 ms, 1025 ± 38 ms, 1144 ± 45 ms (P < 0.0001) and ECV 28.4 ± 3.0% [95% confidence interval (CI) 27.8-29.0], 27.3 ± 2.7 (95% CI 26.8-27.9), 24.1 ± 2.9% (95% CI 23.5-24.7) (P < 0.0001), with all values higher in females for all techniques (T1 +18 ms, +35 ms, +51 ms; ECV +2.7%, +2.6%, +3.4%). Native myocardial T1 reduced slightly with age (R2 = 0.042, P = 0.048; R2 = 0.131, P < 0.0001-on average by 8-11 ms/decade-but not for SASHA (R2 = 0.033 and P = 0.083). ECV did not change with age (R2 = 0.003, P = 0.582; R2 = 0.002, P = 0.689; R2 = 0.003, P = 0.615). Heart rate decreased slightly with age (R2 = 0.075, coefficient = -0.273, P = 0.008), but there was no relationship between age and other blood T1 influences (haematocrit, iron, high density lipoprotein-cholesterol).</p> <h4>Conclusion</h4> <p>Gender influences native T1 and ECV with women having a higher native T1 and ECV. Native T1 measured by MOLLI and ShMOLLI was slightly lower with increasing age but not with SASHA and ECV was independent of age for all techniques.</p> |
| first_indexed | 2024-03-07T02:20:06Z |
| format | Journal article |
| id | oxford-uuid:a39d30b7-94d7-4d16-9fa8-668f188b86d4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:20:06Z |
| publishDate | 2018 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:a39d30b7-94d7-4d16-9fa8-668f188b86d42022-03-27T02:28:18ZMyocardial native T1 and extracellular volume with healthy ageing and genderJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a39d30b7-94d7-4d16-9fa8-668f188b86d4EnglishSymplectic Elements at OxfordOxford University Press2018Rosmini, SBulluck, HCaptur, GTreibel, TAbdel-Gadir, ABhuva, ACulotta, VMerghani, AFontana, MMaestrini, VHerrey, AChow, KThompson, RPiechnik, SKellman, PManisty, CMoon, J <h4>Aims</h4> <p>To determine how native myocardial T1 and extracellular volume (ECV) change with age, both to understand aging and to inform on normal reference ranges.</p> <h4>Methods and results</h4> <p>Ninety-four healthy volunteers with no a history or symptoms of cardiovascular disease or diabetes underwent cardiovascular magnetic resonance at 1.5 T. Mid-ventricular short axis native and post-contrast T1 maps by Shortened MOdified Look-Locker Inversion-recovery (ShMOLLI), MOdified Look-Locker Inversion Recovery (MOLLI) [pre-contrast: 5s(3s)3s, post-contrast: 4s(1s)3s(1s)2s] and saturation recovery single-shot acquisition (SASHA) were acquired and ECV by these three techniques were derived for the mid anteroseptum. Mean age was 50 ± 14 years (range 20-76), male 52%, with no age difference between genders (males 51 ± 14 years; females 49 ± 15 years, P = 0.55). Quoting respectively ShMOLLI, MOLLI, SASHA throughout, mean myocardial T1 was 957 ± 30 ms, 1025 ± 38 ms, 1144 ± 45 ms (P < 0.0001) and ECV 28.4 ± 3.0% [95% confidence interval (CI) 27.8-29.0], 27.3 ± 2.7 (95% CI 26.8-27.9), 24.1 ± 2.9% (95% CI 23.5-24.7) (P < 0.0001), with all values higher in females for all techniques (T1 +18 ms, +35 ms, +51 ms; ECV +2.7%, +2.6%, +3.4%). Native myocardial T1 reduced slightly with age (R2 = 0.042, P = 0.048; R2 = 0.131, P < 0.0001-on average by 8-11 ms/decade-but not for SASHA (R2 = 0.033 and P = 0.083). ECV did not change with age (R2 = 0.003, P = 0.582; R2 = 0.002, P = 0.689; R2 = 0.003, P = 0.615). Heart rate decreased slightly with age (R2 = 0.075, coefficient = -0.273, P = 0.008), but there was no relationship between age and other blood T1 influences (haematocrit, iron, high density lipoprotein-cholesterol).</p> <h4>Conclusion</h4> <p>Gender influences native T1 and ECV with women having a higher native T1 and ECV. Native T1 measured by MOLLI and ShMOLLI was slightly lower with increasing age but not with SASHA and ECV was independent of age for all techniques.</p> |
| spellingShingle | Rosmini, S Bulluck, H Captur, G Treibel, T Abdel-Gadir, A Bhuva, A Culotta, V Merghani, A Fontana, M Maestrini, V Herrey, A Chow, K Thompson, R Piechnik, S Kellman, P Manisty, C Moon, J Myocardial native T1 and extracellular volume with healthy ageing and gender |
| title | Myocardial native T1 and extracellular volume with healthy ageing and gender |
| title_full | Myocardial native T1 and extracellular volume with healthy ageing and gender |
| title_fullStr | Myocardial native T1 and extracellular volume with healthy ageing and gender |
| title_full_unstemmed | Myocardial native T1 and extracellular volume with healthy ageing and gender |
| title_short | Myocardial native T1 and extracellular volume with healthy ageing and gender |
| title_sort | myocardial native t1 and extracellular volume with healthy ageing and gender |
| work_keys_str_mv | AT rosminis myocardialnativet1andextracellularvolumewithhealthyageingandgender AT bulluckh myocardialnativet1andextracellularvolumewithhealthyageingandgender AT capturg myocardialnativet1andextracellularvolumewithhealthyageingandgender AT treibelt myocardialnativet1andextracellularvolumewithhealthyageingandgender AT abdelgadira myocardialnativet1andextracellularvolumewithhealthyageingandgender AT bhuvaa myocardialnativet1andextracellularvolumewithhealthyageingandgender AT culottav myocardialnativet1andextracellularvolumewithhealthyageingandgender AT merghania myocardialnativet1andextracellularvolumewithhealthyageingandgender AT fontanam myocardialnativet1andextracellularvolumewithhealthyageingandgender AT maestriniv myocardialnativet1andextracellularvolumewithhealthyageingandgender AT herreya myocardialnativet1andextracellularvolumewithhealthyageingandgender AT chowk myocardialnativet1andextracellularvolumewithhealthyageingandgender AT thompsonr myocardialnativet1andextracellularvolumewithhealthyageingandgender AT piechniks myocardialnativet1andextracellularvolumewithhealthyageingandgender AT kellmanp myocardialnativet1andextracellularvolumewithhealthyageingandgender AT manistyc myocardialnativet1andextracellularvolumewithhealthyageingandgender AT moonj myocardialnativet1andextracellularvolumewithhealthyageingandgender |