A multiscale model for collagen alignment in wound healing
It is thought that collagen alignment plays a significant part in scar tissue formation during dermal wound healing. We present a multiscale model for collagen deposition and alignment during this process. We consider fibroblasts as discrete units moving within an extracellular matrix of collagen an...
| Những tác giả chính: | , , |
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| Định dạng: | Journal article |
| Được phát hành: |
2005
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| _version_ | 1826288867263643648 |
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| author | Maini, P Dallon, J Sherratt, J |
| author_facet | Maini, P Dallon, J Sherratt, J |
| author_sort | Maini, P |
| collection | OXFORD |
| description | It is thought that collagen alignment plays a significant part in scar tissue formation during dermal wound healing. We present a multiscale model for collagen deposition and alignment during this process. We consider fibroblasts as discrete units moving within an extracellular matrix of collagen and fibrin modelled as continua. Our model includes flux induced alignment of collagen by fibroblasts, and contact guidance of fibroblasts by collagen fibres. We can use the model to predict the effects of certain manipulations, such as varying fibroblast speed, or placing an aligned piece of tissue in the wound. We also simulate experiments which alter the TGF-β concentrations in a healing dermal wound and use the model to offer an explanation of the observed influence of this growth factor on scarring. |
| first_indexed | 2024-03-07T02:20:12Z |
| format | Journal article |
| id | oxford-uuid:a3a79e9e-ca0d-42f9-bec9-ad70fbd908f9 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T02:20:12Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:a3a79e9e-ca0d-42f9-bec9-ad70fbd908f92022-03-27T02:28:33ZA multiscale model for collagen alignment in wound healingJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a3a79e9e-ca0d-42f9-bec9-ad70fbd908f9Mathematical Institute - ePrints2005Maini, PDallon, JSherratt, JIt is thought that collagen alignment plays a significant part in scar tissue formation during dermal wound healing. We present a multiscale model for collagen deposition and alignment during this process. We consider fibroblasts as discrete units moving within an extracellular matrix of collagen and fibrin modelled as continua. Our model includes flux induced alignment of collagen by fibroblasts, and contact guidance of fibroblasts by collagen fibres. We can use the model to predict the effects of certain manipulations, such as varying fibroblast speed, or placing an aligned piece of tissue in the wound. We also simulate experiments which alter the TGF-β concentrations in a healing dermal wound and use the model to offer an explanation of the observed influence of this growth factor on scarring. |
| spellingShingle | Maini, P Dallon, J Sherratt, J A multiscale model for collagen alignment in wound healing |
| title | A multiscale model for collagen alignment in wound healing |
| title_full | A multiscale model for collagen alignment in wound healing |
| title_fullStr | A multiscale model for collagen alignment in wound healing |
| title_full_unstemmed | A multiscale model for collagen alignment in wound healing |
| title_short | A multiscale model for collagen alignment in wound healing |
| title_sort | multiscale model for collagen alignment in wound healing |
| work_keys_str_mv | AT mainip amultiscalemodelforcollagenalignmentinwoundhealing AT dallonj amultiscalemodelforcollagenalignmentinwoundhealing AT sherrattj amultiscalemodelforcollagenalignmentinwoundhealing AT mainip multiscalemodelforcollagenalignmentinwoundhealing AT dallonj multiscalemodelforcollagenalignmentinwoundhealing AT sherrattj multiscalemodelforcollagenalignmentinwoundhealing |