Liposome treatment of viral infections
One can treat a viral infection such as hepatitis B (HBV), hepatitis C (HCV), and bovine viral diarrhea virus (BVDV) infections via the delivery of pH sensitive liposomes directly into the endoplasmic reticulum (ER) membrane. Two exemplary liposome formulations are DOPE/CHEMS (DC liposomes) and DOPE...
| Main Authors: | , , , , , , |
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| Format: | Patent |
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European Patent Office
2011
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| _version_ | 1797086316208324608 |
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| author | Dwek, R Nichita-Branza, N Petrescu, S Pollock, S Rudd, P Scanlan, C Zitzmann, N |
| author_facet | Dwek, R Nichita-Branza, N Petrescu, S Pollock, S Rudd, P Scanlan, C Zitzmann, N |
| author_sort | Dwek, R |
| collection | OXFORD |
| description | One can treat a viral infection such as hepatitis B (HBV), hepatitis C (HCV), and bovine viral diarrhea virus (BVDV) infections via the delivery of pH sensitive liposomes directly into the endoplasmic reticulum (ER) membrane. Two exemplary liposome formulations are DOPE/CHEMS (DC liposomes) and DOPE/CHEMS/PEG-PE (DCPP liposomes). DC and DCPP liposomes can optimize the intracellular delivery of N -butyl deoxynojirimycin (NB-DNJ), and consequently increase the in vivo activity of this iminosugar several orders of magnitude, and could be used in combination with other therapeutic agents such as interferon and/or ribavirin. The optimized release of N B-DNJ directly into the ER can be also applied for the treatment of other viruses, for which NB-DNJ is known to be an effective antiviral, such as human immunodeficiency virus (HIV). |
| first_indexed | 2024-03-07T02:20:15Z |
| format | Patent |
| id | oxford-uuid:a3ac1d57-211b-4cbe-83e2-ecf6db840218 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T02:20:15Z |
| publishDate | 2011 |
| publisher | European Patent Office |
| record_format | dspace |
| spelling | oxford-uuid:a3ac1d57-211b-4cbe-83e2-ecf6db8402182022-03-27T02:28:39ZLiposome treatment of viral infectionsPatenthttp://purl.org/coar/resource_type/c_15cduuid:a3ac1d57-211b-4cbe-83e2-ecf6db840218Symplectic Elements at OxfordEuropean Patent Office2011Dwek, RNichita-Branza, NPetrescu, SPollock, SRudd, PScanlan, CZitzmann, NOne can treat a viral infection such as hepatitis B (HBV), hepatitis C (HCV), and bovine viral diarrhea virus (BVDV) infections via the delivery of pH sensitive liposomes directly into the endoplasmic reticulum (ER) membrane. Two exemplary liposome formulations are DOPE/CHEMS (DC liposomes) and DOPE/CHEMS/PEG-PE (DCPP liposomes). DC and DCPP liposomes can optimize the intracellular delivery of N -butyl deoxynojirimycin (NB-DNJ), and consequently increase the in vivo activity of this iminosugar several orders of magnitude, and could be used in combination with other therapeutic agents such as interferon and/or ribavirin. The optimized release of N B-DNJ directly into the ER can be also applied for the treatment of other viruses, for which NB-DNJ is known to be an effective antiviral, such as human immunodeficiency virus (HIV). |
| spellingShingle | Dwek, R Nichita-Branza, N Petrescu, S Pollock, S Rudd, P Scanlan, C Zitzmann, N Liposome treatment of viral infections |
| title | Liposome treatment of viral infections |
| title_full | Liposome treatment of viral infections |
| title_fullStr | Liposome treatment of viral infections |
| title_full_unstemmed | Liposome treatment of viral infections |
| title_short | Liposome treatment of viral infections |
| title_sort | liposome treatment of viral infections |
| work_keys_str_mv | AT dwekr liposometreatmentofviralinfections AT nichitabranzan liposometreatmentofviralinfections AT petrescus liposometreatmentofviralinfections AT pollocks liposometreatmentofviralinfections AT ruddp liposometreatmentofviralinfections AT scanlanc liposometreatmentofviralinfections AT zitzmannn liposometreatmentofviralinfections |