Towards whole-organ modelling of tumour growth
Multiscale approaches to modelling biological phenomena are growing rapidly. We present here some recent results on the formulation of a theoretical framework which can be developed into a fully integrative model for cancer growth. The model takes account of vascular adaptation and cell-cycle dynami...
| Main Authors: | , , |
|---|---|
| Format: | Journal article |
| Published: |
2004
|
| _version_ | 1826288907686248448 |
|---|---|
| author | Alarcon, T Byrne, H Maini, P |
| author_facet | Alarcon, T Byrne, H Maini, P |
| author_sort | Alarcon, T |
| collection | OXFORD |
| description | Multiscale approaches to modelling biological phenomena are growing rapidly. We present here some recent results on the formulation of a theoretical framework which can be developed into a fully integrative model for cancer growth. The model takes account of vascular adaptation and cell-cycle dynamics. We explore the effects of spatial inhomogeneity induced by the blood flow through the vascular network and of the possible effects of p27 on the cell cycle. We show how the model may be used to investigate the efficiency of drug-delivery protocols. |
| first_indexed | 2024-03-07T02:20:49Z |
| format | Journal article |
| id | oxford-uuid:a3d95e8d-933c-405d-8ed3-3086bc6ee6be |
| institution | University of Oxford |
| last_indexed | 2024-03-07T02:20:49Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:a3d95e8d-933c-405d-8ed3-3086bc6ee6be2022-03-27T02:29:56ZTowards whole-organ modelling of tumour growthJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a3d95e8d-933c-405d-8ed3-3086bc6ee6beMathematical Institute - ePrints2004Alarcon, TByrne, HMaini, PMultiscale approaches to modelling biological phenomena are growing rapidly. We present here some recent results on the formulation of a theoretical framework which can be developed into a fully integrative model for cancer growth. The model takes account of vascular adaptation and cell-cycle dynamics. We explore the effects of spatial inhomogeneity induced by the blood flow through the vascular network and of the possible effects of p27 on the cell cycle. We show how the model may be used to investigate the efficiency of drug-delivery protocols. |
| spellingShingle | Alarcon, T Byrne, H Maini, P Towards whole-organ modelling of tumour growth |
| title | Towards whole-organ modelling of tumour growth |
| title_full | Towards whole-organ modelling of tumour growth |
| title_fullStr | Towards whole-organ modelling of tumour growth |
| title_full_unstemmed | Towards whole-organ modelling of tumour growth |
| title_short | Towards whole-organ modelling of tumour growth |
| title_sort | towards whole organ modelling of tumour growth |
| work_keys_str_mv | AT alarcont towardswholeorganmodellingoftumourgrowth AT byrneh towardswholeorganmodellingoftumourgrowth AT mainip towardswholeorganmodellingoftumourgrowth |