Osteopontin is not required for the development of Th1 responses and viral immunity.
Osteopontin (OPN) has been defined as a key cytokine promoting the release of IL-12 and hence inducing the development of protective cell-mediated immunity to viruses and intracellular pathogens. To further characterize the role of OPN in antiviral immunity, OPN-deficient (OPN-/-) mice were analyzed...
| Päätekijät: | , , , , |
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| Aineistotyyppi: | Journal article |
| Kieli: | English |
| Julkaistu: |
2005
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| _version_ | 1826288908663521280 |
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| author | Abel, B Freigang, S Bachmann, M Boschert, U Kopf, M |
| author_facet | Abel, B Freigang, S Bachmann, M Boschert, U Kopf, M |
| author_sort | Abel, B |
| collection | OXFORD |
| description | Osteopontin (OPN) has been defined as a key cytokine promoting the release of IL-12 and hence inducing the development of protective cell-mediated immunity to viruses and intracellular pathogens. To further characterize the role of OPN in antiviral immunity, OPN-deficient (OPN-/-) mice were analyzed after infection with influenza virus and vaccinia virus. Surprisingly, we found that viral clearance, lung inflammation, and recruitment of effector T cells to the lung were unaffected in OPN-/- mice after influenza infection. Furthermore, effector status of T cells was normal as demonstrated by normal IFN-gamma production and CTL lytic activity. Moreover, activation and Th1 differentiation of naive TCR transgenic CD4+ T cells by dendritic cells and cognate Ag was normal in the absence of OPN in vitro. Contrary to a previous report, we found that OPN-/- mice mounted a normal immune response to Listeria monocytogenes. In conclusion, OPN is dispensable for antiviral immune responses against influenza virus and vaccinia virus. |
| first_indexed | 2024-03-07T02:20:50Z |
| format | Journal article |
| id | oxford-uuid:a3dae49e-2ed2-4448-a10a-01243d51e3f3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:20:50Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:a3dae49e-2ed2-4448-a10a-01243d51e3f32022-03-27T02:29:58ZOsteopontin is not required for the development of Th1 responses and viral immunity.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a3dae49e-2ed2-4448-a10a-01243d51e3f3EnglishSymplectic Elements at Oxford2005Abel, BFreigang, SBachmann, MBoschert, UKopf, MOsteopontin (OPN) has been defined as a key cytokine promoting the release of IL-12 and hence inducing the development of protective cell-mediated immunity to viruses and intracellular pathogens. To further characterize the role of OPN in antiviral immunity, OPN-deficient (OPN-/-) mice were analyzed after infection with influenza virus and vaccinia virus. Surprisingly, we found that viral clearance, lung inflammation, and recruitment of effector T cells to the lung were unaffected in OPN-/- mice after influenza infection. Furthermore, effector status of T cells was normal as demonstrated by normal IFN-gamma production and CTL lytic activity. Moreover, activation and Th1 differentiation of naive TCR transgenic CD4+ T cells by dendritic cells and cognate Ag was normal in the absence of OPN in vitro. Contrary to a previous report, we found that OPN-/- mice mounted a normal immune response to Listeria monocytogenes. In conclusion, OPN is dispensable for antiviral immune responses against influenza virus and vaccinia virus. |
| spellingShingle | Abel, B Freigang, S Bachmann, M Boschert, U Kopf, M Osteopontin is not required for the development of Th1 responses and viral immunity. |
| title | Osteopontin is not required for the development of Th1 responses and viral immunity. |
| title_full | Osteopontin is not required for the development of Th1 responses and viral immunity. |
| title_fullStr | Osteopontin is not required for the development of Th1 responses and viral immunity. |
| title_full_unstemmed | Osteopontin is not required for the development of Th1 responses and viral immunity. |
| title_short | Osteopontin is not required for the development of Th1 responses and viral immunity. |
| title_sort | osteopontin is not required for the development of th1 responses and viral immunity |
| work_keys_str_mv | AT abelb osteopontinisnotrequiredforthedevelopmentofth1responsesandviralimmunity AT freigangs osteopontinisnotrequiredforthedevelopmentofth1responsesandviralimmunity AT bachmannm osteopontinisnotrequiredforthedevelopmentofth1responsesandviralimmunity AT boschertu osteopontinisnotrequiredforthedevelopmentofth1responsesandviralimmunity AT kopfm osteopontinisnotrequiredforthedevelopmentofth1responsesandviralimmunity |