Macrophage heterogeneity in the context of rheumatoid arthritis
Macrophages are very important in the pathogenesis of rheumatoid arthritis (RA). The increase in the number of sublining macrophages in the synovium is an early hallmark of active rheumatic disease, and high numbers of macrophages are a prominent feature of inflammatory lesions. The degree of synovi...
| Main Authors: | , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Nature Publishing Group
2016
|
| _version_ | 1797086357447770112 |
|---|---|
| author | Udalova, I Mantovani, A Feldmann, M |
| author_facet | Udalova, I Mantovani, A Feldmann, M |
| author_sort | Udalova, I |
| collection | OXFORD |
| description | Macrophages are very important in the pathogenesis of rheumatoid arthritis (RA). The increase in the number of sublining macrophages in the synovium is an early hallmark of active rheumatic disease, and high numbers of macrophages are a prominent feature of inflammatory lesions. The degree of synovial macrophage infiltration correlates with the degree of joint erosion, and depletion of these macrophages from inflamed tissue has a profound therapeutic benefit. Research has now uncovered an unexpectedly high level of heterogeneity in macrophage origin and function, and has emphasized the role of environmental factors in their functional specialization. Although the heterogeneous populations of macrophages in RA have not been fully characterized, preliminary results in mouse models of arthritis have contributed to our understanding of the phenotype and ontogeny of synovial macrophages, and to deciphering the properties of monocyte-derived infiltrating and tissue-resident macrophages. Elucidating the molecular mechanisms that drive polarization of macrophages towards proinflammatory or anti-inflammatory phenotypes could lead to identification of signalling pathways that inform future therapeutic strategies. |
| first_indexed | 2024-03-07T02:20:52Z |
| format | Journal article |
| id | oxford-uuid:a3dca7d1-7ad4-46db-a64a-473728a328ad |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:20:52Z |
| publishDate | 2016 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:a3dca7d1-7ad4-46db-a64a-473728a328ad2022-03-27T02:30:01ZMacrophage heterogeneity in the context of rheumatoid arthritisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a3dca7d1-7ad4-46db-a64a-473728a328adEnglishSymplectic Elements at OxfordNature Publishing Group2016Udalova, IMantovani, AFeldmann, MMacrophages are very important in the pathogenesis of rheumatoid arthritis (RA). The increase in the number of sublining macrophages in the synovium is an early hallmark of active rheumatic disease, and high numbers of macrophages are a prominent feature of inflammatory lesions. The degree of synovial macrophage infiltration correlates with the degree of joint erosion, and depletion of these macrophages from inflamed tissue has a profound therapeutic benefit. Research has now uncovered an unexpectedly high level of heterogeneity in macrophage origin and function, and has emphasized the role of environmental factors in their functional specialization. Although the heterogeneous populations of macrophages in RA have not been fully characterized, preliminary results in mouse models of arthritis have contributed to our understanding of the phenotype and ontogeny of synovial macrophages, and to deciphering the properties of monocyte-derived infiltrating and tissue-resident macrophages. Elucidating the molecular mechanisms that drive polarization of macrophages towards proinflammatory or anti-inflammatory phenotypes could lead to identification of signalling pathways that inform future therapeutic strategies. |
| spellingShingle | Udalova, I Mantovani, A Feldmann, M Macrophage heterogeneity in the context of rheumatoid arthritis |
| title | Macrophage heterogeneity in the context of rheumatoid arthritis |
| title_full | Macrophage heterogeneity in the context of rheumatoid arthritis |
| title_fullStr | Macrophage heterogeneity in the context of rheumatoid arthritis |
| title_full_unstemmed | Macrophage heterogeneity in the context of rheumatoid arthritis |
| title_short | Macrophage heterogeneity in the context of rheumatoid arthritis |
| title_sort | macrophage heterogeneity in the context of rheumatoid arthritis |
| work_keys_str_mv | AT udalovai macrophageheterogeneityinthecontextofrheumatoidarthritis AT mantovania macrophageheterogeneityinthecontextofrheumatoidarthritis AT feldmannm macrophageheterogeneityinthecontextofrheumatoidarthritis |