MyD88 adaptor-like D96N is a naturally occurring loss-of-function variant of TIRAP.
Signals elicited by TLRs following the detection of microbes are integrated and diversified by a group of four cytoplasmic adaptor molecules featuring an evolutionarily conserved Toll/IL-1R signaling domain. Single nucleotide polymorphisms (SNPs) in TLRs and their adaptor molecules have been shown t...
Autors principals: | George, J, Kubarenko, A, Rautanen, A, Mills, T, Colak, E, Kempf, T, Hill, A, Nieters, A, Weber, A |
---|---|
Format: | Journal article |
Idioma: | English |
Publicat: |
2010
|
Ítems similars
-
Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly.
per: George, J, et al.
Publicat: (2011) -
The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis.
per: Sacre, S, et al.
Publicat: (2007) -
Hyaluronan signaling during ozone-induced lung injury requires TLR4, MyD88, and TIRAP.
per: Zhuowei Li, et al.
Publicat: (2011-01-01) -
Exploring TLR adaptor protein MyD88 as a sensitivity determinant to HDAC inhibitors
per: Bekheet, M
Publicat: (2017) -
Investigation of interactions between TLR2, MyD88 and TIRAP by bioluminescence resonance energy transfer is hampered by artefacts of protein overexpression
per: Sampaio, N, et al.
Publicat: (2018)