MyD88 adaptor-like D96N is a naturally occurring loss-of-function variant of TIRAP.

MyD88 adaptor-like D96N is a naturally occurring loss-of-function variant of TIRAP.

Signals elicited by TLRs following the detection of microbes are integrated and diversified by a group of four cytoplasmic adaptor molecules featuring an evolutionarily conserved Toll/IL-1R signaling domain. Single nucleotide polymorphisms (SNPs) in TLRs and their adaptor molecules have been shown t...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	George, J, Kubarenko, A, Rautanen, A, Mills, T, Colak, E, Kempf, T, Hill, A, Nieters, A, Weber, A
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	2010

समान संसाधन

Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly.
द्वारा: George, J, और अन्य
प्रकाशित: (2011)

The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis.
द्वारा: Sacre, S, और अन्य
प्रकाशित: (2007)

Hyaluronan signaling during ozone-induced lung injury requires TLR4, MyD88, and TIRAP.
द्वारा: Zhuowei Li, और अन्य
प्रकाशित: (2011-01-01)

Exploring TLR adaptor protein MyD88 as a sensitivity determinant to HDAC inhibitors
द्वारा: Bekheet, M
प्रकाशित: (2017)

Investigation of interactions between TLR2, MyD88 and TIRAP by bioluminescence resonance energy transfer is hampered by artefacts of protein overexpression
द्वारा: Sampaio, N, और अन्य
प्रकाशित: (2018)

Investigation of interactions between TLR2, MyD88 and TIRAP by bioluminescence resonance energy transfer is hampered by artefacts of protein overexpression.
द्वारा: Natália G Sampaio, और अन्य
प्रकाशित: (2018-01-01)

Schisandrin B Attenuates Diabetic Cardiomyopathy by Targeting MyD88 and Inhibiting MyD88‐Dependent Inflammation
द्वारा: Wu Luo, और अन्य
प्रकाशित: (2022-11-01)

Downregulation of adaptor protein MyD88 compromises the angiogenic potential of B16 murine melanoma.
द्वारा: Lucas Daniel Trucco, और अन्य
प्रकाशित: (2017-01-01)

Plasmodium falciparum Malaria Susceptibility and Severity: Influence of MyD88-Adaptor-Like Gene (rs8177374) Polymorphism
द्वारा: Ammar AI, और अन्य
प्रकाशित: (2022-11-01)

The cationic liposome CCS/C adjuvant induces immunity to influenza independently of the adaptor protein MyD88
द्वारा: Orli Even-Or, और अन्य
प्रकाशित: (2020-12-01)

MyD88 Adaptor Protein Is Required for Appropriate Hepcidin Induction in Response to Dietary Iron Overload in Mice
द्वारा: Antonio Layoun, और अन्य
प्रकाशित: (2018-03-01)

Soyasaponins reduce inflammation by downregulating MyD88 expression and suppressing the recruitments of TLR4 and MyD88 into lipid rafts
द्वारा: Junbin Chen, और अन्य
प्रकाशित: (2020-06-01)

Role of MyD88-adaptor-like gene polymorphism rs8177374 in modulation of malaria severity in the Pakistani population
द्वारा: Asima Rani, और अन्य
प्रकाशित: (2017-07-01)

Lipopolysaccharide-induced NF-κB nuclear translocation is primarily dependent on MyD88, but TNFα expression requires TRIF and MyD88
द्वारा: Jiro Sakai, और अन्य
प्रकाशित: (2017-05-01)

Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP.
द्वारा: Andreakos, E, और अन्य
प्रकाशित: (2004)

MyD88 contribution to ocular surface homeostasis.
द्वारा: Rose Y Reins, और अन्य
प्रकाशित: (2017-01-01)

MyD 88 Polymorphisms in Children Diagnosed with Sepsis
द्वारा: Sinem Sarı Gökay, और अन्य
प्रकाशित: (2016-12-01)

Mechanism of MyD88S mediated signal termination
द्वारा: Katarzyna Pustelny, और अन्य
प्रकाशित: (2022-01-01)

Biochanin A Reduces Inflammatory Injury and Neuronal Apoptosis following Subarachnoid Hemorrhage via Suppression of the TLRs/TIRAP/MyD88/NF-κB Pathway
द्वारा: Ling-yun Wu, और अन्य
प्रकाशित: (2018-01-01)

Paradoxical Roles of the MAL/Tirap Adaptor in Pathologies
द्वारा: Imène Belhaouane, और अन्य
प्रकाशित: (2020-09-01)

The TLR adaptor protein MyD88 mediates cell sensitivity to HDAC inhibitors through a cytokine-dependent mechanism
द्वारा: Sheikh, S, और अन्य
प्रकाशित: (2016)

Pathological mutations differentially affect the self-assembly and polymerisation of the innate immune system signalling adaptor molecule MyD88
द्वारा: Ailís O’Carroll, और अन्य
प्रकाशित: (2018-12-01)

MyD88-adaptor protein acts as a preventive mechanism for memory deficits in a mouse model of Alzheimer's disease
द्वारा: Rivest Serge, और अन्य
प्रकाशित: (2011-01-01)

Blocking MyD88 signaling with MyD88 inhibitor prevents colitis-associated colorectal cancer development by maintaining colonic microbiota homeostasis
द्वारा: Bin Xie, और अन्य
प्रकाशित: (2023-12-01)

Pyogenic bacterial infections in humans with MyD88 deficiency.
द्वारा: von Bernuth, H, और अन्य
प्रकाशित: (2008)

MyD88 signaling pathways: role in breast cancer
द्वारा: Hongmei Zheng, और अन्य
प्रकाशित: (2024-01-01)

MyD88 and Its Inhibitors in Cancer: Prospects and Challenges
द्वारा: Jiali Song, और अन्य
प्रकाशित: (2024-05-01)

MyD88 signalling is critical in the development of pancreatic cancer cachexia
द्वारा: Xinxia Zhu, और अन्य
प्रकाशित: (2019-04-01)

Ischemia-reperfusion lung injury is attenuated in MyD88-deficient mice.
द्वारा: William A Altemeier, और अन्य
प्रकाशित: (2013-01-01)

Induction of Hypergammaglobulinemia and Autoantibodies by Salmonella Infection in MyD88-Deficient Mice
द्वारा: Jincy M. Issac, और अन्य
प्रकाशित: (2018-06-01)

MyD88-dependent autoimmune disease in Lyn-deficient mice.
द्वारा: Silver, K, और अन्य
प्रकाशित: (2007)

Inflammatory Role of TLR-MyD88 Signaling in Multiple Sclerosis
द्वारा: Chao Zheng, और अन्य
प्रकाशित: (2020-01-01)

MyD88-dependent pathways in leukocytes affect the retina in diabetes.
द्वारा: Jie Tang, और अन्य
प्रकाशित: (2013-01-01)

The MyD88+ phenotype is an adverse prognostic factor in epithelial ovarian cancer.
द्वारा: Charles J d'Adhemar, और अन्य
प्रकाशित: (2014-01-01)

Myeloid differentiation factor 88 (MyD88)-deficiency increases risk of diabetes in mice.
द्वारा: Toru Hosoi, और अन्य
प्रकाशित: (2010-01-01)

Evidence for a DC-specific inhibitory mechanism that depends on MyD88 and SIGIRR.
द्वारा: Drexler, S, और अन्य
प्रकाशित: (2010)

MyD88 Regulates the Expression of SMAD4 and the Iron Regulatory Hormone Hepcidin
द्वारा: Macha Samba-Mondonga, और अन्य
प्रकाशित: (2018-08-01)

Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency.
द्वारा: Picard, C, और अन्य
प्रकाशित: (2010)

Scallop IKK1 Responds to Bacterial and Virus-Related Pathogen Stimulation and Interacts With MyD88 Adaptor of Toll-Like Receptor Pathway Signaling
द्वारा: Lingling Li, और अन्य
प्रकाशित: (2022-03-01)

Pivotal role of Toll-like receptors 2 and 4, its adaptor molecule MyD88, and inflammasome complex in experimental tubule-interstitial nephritis.
द्वारा: Matheus Correa-Costa, और अन्य
प्रकाशित: (2011-01-01)