Soluble IGF2 receptor rescues Apc(Min/+) intestinal adenoma progression induced by Igf2 loss of imprinting.
The potent growth-promoting activity of insulin-like growth factor-II (IGF-II) is highly regulated during development but frequently up-regulated in tumors. Increased expression of the normally monoallelic (paternally expressed) mouse (Igf2) and human (IGF2) genes modify progression of intestinal ad...
Main Authors: | Harper, J, Burns, J, Foulstone, E, Pignatelli, M, Zaina, S, Hassan, A |
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格式: | Journal article |
语言: | English |
出版: |
2006
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