The impact of the COVID-19 pandemic on vaccine coverage in Kilifi, Kenya: A retrospective cohort study
<p>The COVID-19 pandemic caused unprecedented disruption in health service delivery, globally. This study sought to provide evidence on the impact of the pandemic on vaccine coverage in Kilifi County, Kenya. We conducted a vaccine coverage survey between April and June 2021 within the Kilifi H...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2023
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| _version_ | 1797110552727650304 |
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| author | Lucinde, RK Karia, B Ouma, N Amadi, D Nyundo, C Mataza, C Nyaguara, A Scott, JAG Gallagher, KE Kagucia, E |
| author_facet | Lucinde, RK Karia, B Ouma, N Amadi, D Nyundo, C Mataza, C Nyaguara, A Scott, JAG Gallagher, KE Kagucia, E |
| author_sort | Lucinde, RK |
| collection | OXFORD |
| description | <p>The COVID-19 pandemic caused unprecedented disruption in health service delivery, globally. This study sought to provide evidence on the impact of the pandemic on vaccine coverage in Kilifi County, Kenya. We conducted a vaccine coverage survey between April and June 2021 within the Kilifi Health and Demographic Surveillance System (KHDSS). Simple random sampling was used to identify 1500 children aged 6 weeks–59 months. Participants were grouped into three retrospective cohorts based on when they became age-eligible for vaccination: before the pandemic, during the first year, or during the second year of the pandemic. Survival analysis with Cox regression was used to evaluate the association between the time-period at which participants became age-eligible for vaccination and the rate of vaccination within a month of age-eligibility for the third dose of pentavalent vaccine (Pentavalent-3) and within three months of age-eligibility for the first dose of Measles vaccine (MCV-1). A total of 1,341 participants were included in the survey. Compared to the pre-COVID-19 baseline period, the rate of vaccination within a month of age-eligibility for Pentavalent-3 was not significantly different in the first year of the pandemic (adjusted hazard ratio [aHR] 1.03, 95 % confidence interval [CI] 0.90–1.18) and was significantly higher during the second year of the pandemic (aHR 1.33, 95 % CI 1.07–1.65). The rate of vaccination with MCV-1 within three months of age-eligibility was not significantly different among those age-eligible for vaccination during the first year of the pandemic (aHR 1.04, 95 % CI 0.88–1.21) and was 35 % higher during the second year of the pandemic (95 % CI 1.11–1.64), compared to those age-eligible pre-COVID-19. After adjusting for known determinants of vaccination, the COVID-19 pandemic did not adversely affect the rate of vaccination within the KHDSS.</p> |
| first_indexed | 2024-03-07T07:56:24Z |
| format | Journal article |
| id | oxford-uuid:a3fe45da-aa16-4141-87d5-65272601b1d1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:56:24Z |
| publishDate | 2023 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:a3fe45da-aa16-4141-87d5-65272601b1d12023-08-16T14:35:25ZThe impact of the COVID-19 pandemic on vaccine coverage in Kilifi, Kenya: A retrospective cohort studyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a3fe45da-aa16-4141-87d5-65272601b1d1EnglishSymplectic ElementsElsevier 2023Lucinde, RKKaria, BOuma, NAmadi, DNyundo, CMataza, CNyaguara, AScott, JAGGallagher, KEKagucia, E<p>The COVID-19 pandemic caused unprecedented disruption in health service delivery, globally. This study sought to provide evidence on the impact of the pandemic on vaccine coverage in Kilifi County, Kenya. We conducted a vaccine coverage survey between April and June 2021 within the Kilifi Health and Demographic Surveillance System (KHDSS). Simple random sampling was used to identify 1500 children aged 6 weeks–59 months. Participants were grouped into three retrospective cohorts based on when they became age-eligible for vaccination: before the pandemic, during the first year, or during the second year of the pandemic. Survival analysis with Cox regression was used to evaluate the association between the time-period at which participants became age-eligible for vaccination and the rate of vaccination within a month of age-eligibility for the third dose of pentavalent vaccine (Pentavalent-3) and within three months of age-eligibility for the first dose of Measles vaccine (MCV-1). A total of 1,341 participants were included in the survey. Compared to the pre-COVID-19 baseline period, the rate of vaccination within a month of age-eligibility for Pentavalent-3 was not significantly different in the first year of the pandemic (adjusted hazard ratio [aHR] 1.03, 95 % confidence interval [CI] 0.90–1.18) and was significantly higher during the second year of the pandemic (aHR 1.33, 95 % CI 1.07–1.65). The rate of vaccination with MCV-1 within three months of age-eligibility was not significantly different among those age-eligible for vaccination during the first year of the pandemic (aHR 1.04, 95 % CI 0.88–1.21) and was 35 % higher during the second year of the pandemic (95 % CI 1.11–1.64), compared to those age-eligible pre-COVID-19. After adjusting for known determinants of vaccination, the COVID-19 pandemic did not adversely affect the rate of vaccination within the KHDSS.</p> |
| spellingShingle | Lucinde, RK Karia, B Ouma, N Amadi, D Nyundo, C Mataza, C Nyaguara, A Scott, JAG Gallagher, KE Kagucia, E The impact of the COVID-19 pandemic on vaccine coverage in Kilifi, Kenya: A retrospective cohort study |
| title | The impact of the COVID-19 pandemic on vaccine coverage in Kilifi, Kenya: A retrospective cohort study |
| title_full | The impact of the COVID-19 pandemic on vaccine coverage in Kilifi, Kenya: A retrospective cohort study |
| title_fullStr | The impact of the COVID-19 pandemic on vaccine coverage in Kilifi, Kenya: A retrospective cohort study |
| title_full_unstemmed | The impact of the COVID-19 pandemic on vaccine coverage in Kilifi, Kenya: A retrospective cohort study |
| title_short | The impact of the COVID-19 pandemic on vaccine coverage in Kilifi, Kenya: A retrospective cohort study |
| title_sort | impact of the covid 19 pandemic on vaccine coverage in kilifi kenya a retrospective cohort study |
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